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Determination of hemispheric dominance using visual event-related potentials (ERPs)

使用视觉事件相关电位 (ERP) 确定半球优势

基本信息

批准号：
06670807
负责人：
MATSUZAKA Tetsuo
金额：
$ 0.26万
依托单位：
Nagasaki University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1994
资助国家：
日本
起止时间：
1994 至 1995
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-06670807/
关键词：
ERP Event-related potential Visual recognition P300 Hemisphere dominance

项目摘要

In order to determine the dominant hemisphere of language and the effect of the temporal lobectomy (TL), event-related potentials (ERP) were recorded in 36 normal subjects and 12 patients received left or right TL (LTL=7, RTL=5). Visual stimuli of verbal ("Kana") and non-verbal ("Dot" in space and "Face") were presented using a tachistoscope and "oddball" paradigm.In normal subjects (right handers), the P300 amplitude were higher in verbal stimulation to right-visual field and in non-verbal stimulation to left-visual field. When verbal (or non-verbal) stimulus was presented, reaction time was shortest (or longest) in right-visual field stimulus (RV)-right hand response (RH), followed by RV-LH,LV-RH,and LV-LH.In patients received TL,P300 amplitude were lower than normal subjects, and hemispheric dominance to verbal and non-verbal stimuli were not observed. Both LTL and RTL patients had longer P300 latency than normal subjects, especially in "Kana" stimulus in LTL and "Dot" in RTL patients. Thses findings suggest that P300 and reaction time to the tachistoscopic visual stimuli could determine the hemispheric dominance and effect of TL.Further study in combination with magnetoencephalography and functional MRI would produce precise localization of cognitive function.

为了确定语言的优势半球和颞叶切除术（TL）的效果，我们记录了36例正常人和12例接受左、右颞叶切除术（LTL=7， RTL=5）的患者的事件相关电位（ERP）。使用速视镜和“古怪”范式呈现语言（“假名”）和非语言（空间中的“点”和“脸”）视觉刺激。正常被试（右撇子）的P300波幅在言语刺激右视野时较高，在非言语刺激左视野时较高。在语言（或非语言）刺激条件下，右视野刺激-右手反应时间最短（或最长），其次为右-左、左-右、左-左。在接受TL治疗的患者中，P300振幅低于正常受试者，并且未观察到对言语和非言语刺激的半球优势。LTL和RTL患者的P300潜伏期均比正常受试者长，尤其是LTL的“假名”刺激和RTL的“Dot”刺激。这些结果表明P300和对视觉刺激的反应时间可以决定大脑半球优势和认知功能的影响，进一步结合脑磁图和功能MRI的研究将得到更精确的认知功能定位。