Judgment of chemotherapeutic effecrs on the viability of malignant bone tumors with T1-201SPECT

T1-201SPECT判断恶性骨肿瘤生存能力的化疗效果

• 批准号: 06670910
• 负责人: TONAMI Norihisa
• 金额: $ 0.64万
• 依托单位: Kanazawa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1994
• 资助国家: 日本
• 起止时间: 1994 至 1995
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-06670910/
• 关键词: T1-201; malignant bone tumor; chemotherapy

The nude mouse model bearing human Ewing's sarcoma was used. T1-201 was injected intravenously and the counts in the blood and the tumor were measured sequentially.T1-201 was rapidly taken up by the tumor and gradually decreased. While the radioactivity in the tumor was increased rapidly up to 10 min after injection and remained higher than that of blood afterward. Tumor uptake of T1-201 was significantly reduced in patients with effective chemotherapy with cis-diamminedichloroplatinum (II) as compared to the control group without treatment although the tumor volume was not affected by 12 days after cis-diamminedichloroplatinum (II) injection. The tumor uptake of T1-201 was proved to be a sensitive indicator for tumor cell activity.Clinical study was performed by injection of T1-201 111MBq in 11 patients with malignant bone or soft tissue tumors before and after 3-5 courses of chemotherapy (cis-diamminedichloroplatinum (II), doxorubicin hydrochloride, caffeine. T1-201 uptake ratio of the tumor to normal tissue in the lesions with remarkable chemotherapeutic effect seems to be smaller compared to the lesions with inappreciable effect.T1-201 scintigrapy seems to reflect chemotherapeutic effect for malignant bone or soft tissue tumors. We will report the final results after the evaluation of chemotherapeutic effect was derermined in all of cases.

采用荷人尤文肉瘤裸鼠模型。静脉注射T1-201后，分别测定血液和肿瘤中的T1-201计数，T1 -201被肿瘤迅速摄取并逐渐减少。而肿瘤内放射性在注射后10 min迅速升高，此后仍高于血液。与未接受治疗的对照组相比，使用顺式二氯二氨铂（II）进行有效化疗的患者的T1-201肿瘤摄取显著降低，尽管顺式二氯二氨铂（II）注射后12天肿瘤体积未受影响。肿瘤摄取T_1 -201是反映肿瘤细胞活性的敏感指标，本文对11例恶性骨或软组织肿瘤患者在化疗（顺铂、盐酸阿霉素、咖啡因）3-5个疗程前、后分别注射T_1 -201 111 MBq进行了临床研究。化疗效果显著的病灶与正常组织T1-201摄取比值小于化疗效果不显著的病灶，T1 - 201显像可反映恶性骨或软组织肿瘤的化疗效果。所有病例均在化疗效果评价后报告最终结果。

项目成果

J.Taki,H.Sumiya,H.Chuchiya,K.Tomita,A.Nonomura,N.Tonami: "Technetium-99m-MIBI scintigraphy in the evaluation of bone and soft tissue lesions : A within-subject comparison with Tl-201" J Nucl Med. (発表予定). (1996)

J.Taki、H.Sumiya、H.Chuchiya、K.Tomita、A.Nonomura、N.Tonami：“Technetium-99m-MIBI 闪烁扫描术在骨和软组织病变评估中的应用：与 Tl-201 的受试者内比较“《J Nucl Med》（即将发表）。（1996）

J.Taki, H.Sumiya, H.Chuchiya, K.Tomita, A.Nonomura, N.Tonami: "Technetium-99m-MIBI scintigraphy in the evaluation of bone and soft lesions : A within-subject comparison with T1-201" J Nucl Med. (in press).

J.Taki、H.Sumiya、H.Chuchiya、K.Tomita、A.Nonomura、N.Tonami：“Technetium-99m-MIBI 闪烁扫描术在骨和软病变评估中的应用：与 T1-201 的受试者内比较”

Junichi Taki,H.Sumiya.H,Tchucliiya.K.Tomita,A.Nonomura N.Tonami: "Technotiurm-99m-MIBI Scinfigraphy in the evaluation of bone and solA tissue les'ons: A within-subject Companison with Tl-201" J. Nucl. Med.(発表予定).

Junichi Taki，H. Sumiya，《J. Nucl. Med.》（即将发表）。