Analysis of bile duct carcinoma using hamster model.

使用仓鼠模型分析胆管癌。

• 批准号: 06671215
• 负责人: TOMIOKA Tsutomu
• 金额: $ 0.38万
• 依托单位: Nagasaki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1994
• 资助国家: 日本
• 起止时间: 1994 至 1995
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-06671215/
• 关键词: bile duct cancer; hamster; 胆管癌; 胆嚢癌; BOP; 肝内胆管癌; 肝外胆管癌; 胆汁酸

Intrahepatic bile duct carcinoma is one of the malignant and rare carcinomas of the digestive system. Not only are these lesions frequently silent and difficult to diagnose, they are often invasive to adjacent ducts and connective tissues, hence, unrespectable. Therefore, there are a few resection cases, and its early growth and invasive patters are still unclear.On the other hand, it is well known that pancreatic tumors induced in Syrian golden hamsters represent an experimental counterpart of human disease morphologically, biologically and immnologically. A new model for the induction of biliary carcinoma in the hamster using N-nitrosobis (2-oxopropyl) amine (BOP) was developed in our laboratory. These bile duct carcinomas induced in hamsters also showed the similarity to the human cancer in morphologic and biologic patterns. We can see the very early stage of the intrahepatic bile duct carcinoma in our new hamster model.To clarify the early growth and invasive patterns of the intrah … More epatic bile duct carcinoma, we investigate the early stage of intrahepatic bile duct carcinoma of the hamster model comparing with the tumors in the human cases.We compared the histo-pathological patterns of the surgically resected secimens of intrahepatic bile duct carcinomas of 22 patients and chemically induced 502 bile duct carcinomas in hamsters to clarify the early growth and invasive patterns. We concluded as follows ;1.The growth patterns were classified into four sub types according to the original sites of tumors ; A)duct infiltrating type, B)mass forming type,C)intraductal growth type, D)periductal gland type.2.Types A and B showed predominant in peripheral region and types A and C were predominant in hilar region.3.A part of cystadenoma, cystadenocarcinoma or mucinous carcinoma might be deroved from the type D.4.Papillary growth pattern in the cavity of the bile duct suggested that the original site of the tumor might be the large duct and the prognosis is much better than other types. Less

肝内胆管癌是消化系统的一种罕见恶性肿瘤。这些病变不仅经常是无声的，难以诊断，他们往往是侵犯邻近导管和结缔组织，因此，不值得尊敬。另一方面，众所周知，在叙利亚金黄地鼠中诱导的胰腺肿瘤在形态学、生物学和免疫学上代表了人类疾病的实验对应物。本实验室用N-亚硝基二（2-氧代丙基）胺（BOP）建立了一种新的仓鼠胆管癌模型。在仓鼠体内诱发的胆管癌在形态学和生物学模式上也与人类胆管癌相似。在我们的新仓鼠模型中，我们可以看到肝内胆管癌的非常早期阶段。为了阐明肝内胆管癌的早期生长和侵袭模式， ...更多信息 为探讨胆管癌的早期生长和浸润特点，我们对22例肝内胆管癌手术切除标本和502例化学诱导的仓鼠胆管癌进行了组织病理学比较。我们的结论如下：1.根据肿瘤的原发部位将肿瘤的生长方式分为四种亚型; A）导管浸润型，B）肿块形成型，C）导管内生长型，D）导管周围腺体型。2.周边区以A、B型为主，肝门区以A、C型为主。3.部分囊腺瘤，D型可衍生为囊腺癌或粘液腺癌。4.胆管腔内乳头状生长提示肿瘤可能起源于大胆管，预后较好比其他类型。少

项目成果

冨岡 勉 他: "肝内胆管癌における早期病変と浸潤形式" 胆と膵. 15(10). 1011-1017 (1994)

Tsutomu Tomioka 等：“肝内胆管癌的早期病变和侵袭形式”Bile and Pancreas 15(10) (1994)。

T.Fukahori, T.Tomioka, K.Inoue, Y,Tajima, T.Tsunoda, T.Kanematsu: "Establishment of a transplantablecarcinoma arisinf from the Intra-hepatic bile duct in Syrian golden hamsters." Virchows Arch A. 422. 232-238 (1993)

T.Fukahori、T.Tomioka、K.Inoue、Y、Tajima、T.Tsunoda、T.Kanematsu：“确定叙利亚金仓鼠肝内胆管存在可移植性癌。”

N.Nakanuma, K.Tsuneyama, S.Masuda, T.Tomioka: "Hepatic infla matory pesudotumor associated with chronic cholangitis." Report of three cases.Hum Pathol.25. 86-91 (1994)

N.Nakanuma、K.Tsuneyama、S.Masuda、T.Tomioka：“与慢性胆管炎相关的肝脏炎症性假瘤。”

Y.Ikematsu, T.Eto, T.Tomioka, T.Matsumoto, T.Tsunoda, T.Kanematsu: "Biliary diverticulum with pancreaticobiliary maljunction." Hepato-Gastroenterol. 41. 70-72 (1994)

Y.Ikematsu、T.Eto、T.Tomioka、T.Matsumoto、T.Tsunoda、T.Kanematsu：“胆道憩室伴胰胆管连接不良。”

T.Tsunoda, T.eto, M.Sasaki, T.Tomioka, S.Matsukawa, T.Segawa, K.Izawa, T.Kanematsu.: "diagnosis and surgical treatment of cholangiocarcinoma." XXVIII World Congress of the International College of Surgeons.783-787 (1994)

T.Tsunoda、T.eto、M.Sasaki、T.Tomioka、S.Matsukawa、T.Sekawa、K.Izawa、T.Kanematsu.：“胆管癌的诊断和手术治疗。”