Analysis of bile duct carcinoma using hamster model.

肝内胆管癌是消化系统少见的恶性肿瘤之一。这些病变不仅经常是沉默的，很难诊断，而且往往侵袭邻近的导管和结缔组织，因此，不受尊重。因此，手术切除的病例很少，其早期生长和侵袭模式尚不清楚。另一方面，众所周知，叙利亚金黄地鼠诱导的胰腺肿瘤在形态、生物学和免疫学上都是人类疾病的实验对应物。本实验室建立了一种新的N-亚硝基双(2-氧丙基)胺(BOP)诱发金黄地鼠胆道癌模型。这些在仓鼠体内诱发的胆管癌在形态和生物学模式上也显示出与人类癌症的相似之处。我们可以在我们的新的仓鼠模型中看到非常早期的肝内胆管癌。为了阐明…的早期生长和侵袭模式为了了解更多的肝内胆管癌，我们研究了仓鼠模型的早期肝内胆管癌，并与人的肿瘤进行了比较。我们比较了22例手术切除的肝内胆管癌和502例化学诱发的仓鼠胆管癌的组织病理学模式，以阐明其早期生长和侵袭模式。根据肿瘤的原发部位可分为四种亚型：A)胆管浸润型，B)肿块形成型，C)胆管内生长型，D)导管周腺型。2.A、B型以外周型为主，A、C型以肝门区为主。3.部分囊腺瘤、囊腺癌或粘液性癌可能与D型不同。4.胆管腔内乳头状生长模式提示肿瘤起源部位可能为大管，预后明显优于其他类型。较少

Intrahepatic bile duct carcinoma is one of the malignant and rare carcinomas of the digestive system. Not only are these lesions frequently silent and difficult to diagnose, they are often invasive to adjacent ducts and connective tissues, hence, unrespectable. Therefore, there are a few resection cases, and its early growth and invasive patters are still unclear.On the other hand, it is well known that pancreatic tumors induced in Syrian golden hamsters represent an experimental counterpart of human disease morphologically, biologically and immnologically. A new model for the induction of biliary carcinoma in the hamster using N-nitrosobis (2-oxopropyl) amine (BOP) was developed in our laboratory. These bile duct carcinomas induced in hamsters also showed the similarity to the human cancer in morphologic and biologic patterns. We can see the very early stage of the intrahepatic bile duct carcinoma in our new hamster model.To clarify the early growth and invasive patterns of the intrah … More epatic bile duct carcinoma, we investigate the early stage of intrahepatic bile duct carcinoma of the hamster model comparing with the tumors in the human cases.We compared the histo-pathological patterns of the surgically resected secimens of intrahepatic bile duct carcinomas of 22 patients and chemically induced 502 bile duct carcinomas in hamsters to clarify the early growth and invasive patterns. We concluded as follows ;1.The growth patterns were classified into four sub types according to the original sites of tumors ; A)duct infiltrating type, B)mass forming type,C)intraductal growth type, D)periductal gland type.2.Types A and B showed predominant in peripheral region and types A and C were predominant in hilar region.3.A part of cystadenoma, cystadenocarcinoma or mucinous carcinoma might be deroved from the type D.4.Papillary growth pattern in the cavity of the bile duct suggested that the original site of the tumor might be the large duct and the prognosis is much better than other types. Less