Analysis of bile duct carcinoma using hamster model.

肝内胆管癌是一种罕见的消化系统恶性肿瘤。这些病变不仅通常无声且难以诊断，而且常常侵入邻近的导管和结缔组织，因此不值得重视。因此，切除病例较少，其早期生长和侵袭方式尚不清楚。另一方面，众所周知，叙利亚金仓鼠诱导的胰腺肿瘤在形态学、生物学和免疫学上代表了人类疾病的实验对应体。本实验室建立了n -亚硝基双（2-氧丙基）胺（BOP）诱导仓鼠胆道癌的新模型。这些在仓鼠体内诱导的胆管癌在形态和生物学模式上也与人类的胆管癌相似。我们可以在新的仓鼠模型中看到肝内胆管癌的早期阶段。为了阐明肝内胆管癌的早期生长和侵袭模式，我们将仓鼠肝内胆管癌模型与人肝内胆管癌模型进行对比研究。我们比较了22例手术切除的肝内胆管癌和502例化学诱导的仓鼠胆管癌的组织病理模式，以阐明其早期生长和侵袭模式。我们得出了以下结论：1。根据肿瘤的原发部位，将肿瘤的生长模式分为4个亚型；A)导管浸润型，B)肿块形成型，C)导管内生长型，D)导管周围腺型。A、B型以外周区为主，A、C型以肺门区为主。部分囊腺瘤、囊腺癌或黏液性癌可起源于D.4型。胆管腔内乳头状生长形态提示肿瘤原发部位可能为大胆管，预后明显好于其他类型。少

Intrahepatic bile duct carcinoma is one of the malignant and rare carcinomas of the digestive system. Not only are these lesions frequently silent and difficult to diagnose, they are often invasive to adjacent ducts and connective tissues, hence, unrespectable. Therefore, there are a few resection cases, and its early growth and invasive patters are still unclear.On the other hand, it is well known that pancreatic tumors induced in Syrian golden hamsters represent an experimental counterpart of human disease morphologically, biologically and immnologically. A new model for the induction of biliary carcinoma in the hamster using N-nitrosobis (2-oxopropyl) amine (BOP) was developed in our laboratory. These bile duct carcinomas induced in hamsters also showed the similarity to the human cancer in morphologic and biologic patterns. We can see the very early stage of the intrahepatic bile duct carcinoma in our new hamster model.To clarify the early growth and invasive patterns of the intrah … More epatic bile duct carcinoma, we investigate the early stage of intrahepatic bile duct carcinoma of the hamster model comparing with the tumors in the human cases.We compared the histo-pathological patterns of the surgically resected secimens of intrahepatic bile duct carcinomas of 22 patients and chemically induced 502 bile duct carcinomas in hamsters to clarify the early growth and invasive patterns. We concluded as follows ;1.The growth patterns were classified into four sub types according to the original sites of tumors ; A)duct infiltrating type, B)mass forming type,C)intraductal growth type, D)periductal gland type.2.Types A and B showed predominant in peripheral region and types A and C were predominant in hilar region.3.A part of cystadenoma, cystadenocarcinoma or mucinous carcinoma might be deroved from the type D.4.Papillary growth pattern in the cavity of the bile duct suggested that the original site of the tumor might be the large duct and the prognosis is much better than other types. Less