Study of Endoscopy-guided LASER Therapy for Intraductal Minimal Lesions of the Breast

内镜引导下乳腺导管内微小病变激光治疗的研究

• 批准号: 06671217
• 负责人: OKAZAKI Akira
• 金额: $ 0.51万
• 依托单位: Sapporo Medical University, School of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1994
• 资助国家: 日本
• 起止时间: 1994 至 1995
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-06671217/
• 关键词: Nipple Discharge; Nonpalpable Breast Cancer; Fiberoptic Ductoscopy Of The Breast; Intraductal Papilloma; LASER Therapy; 乳頭内乳頭腫

Intraductal papilloma (papilloma) is an main cause of nipple discharge with no palpable mass. The method of endoscopy-guided LASER therapy which was one of non-surgical treatments for papilloma, was studied as well as the possibility of its clinical use. Most of papilloma grew in the lactiferous duct near the nipple and the spreading size was less than 2.0cm. Furthermore, many papilloma showed a filling defect on ductogram and a hemisphere nodule on endoscopic examination. Indication of LASER therapy was as follows ; 1) Solitary filling defect or interruption by filling defect on ductogram near the nipple, 2) Hemisphere nodule on fiberoptic ductoscopy, 3) Results of tube curette cytology is benign. After the informed consent of the LASER therapy, it was performed. The equipment of the LASER therapy was as follows : The diameter of endoscope was 0.65mm or 0.75mm and LASER fiber (outer diameter was 0.20mm) was introduced through the air channnel of the endoscope. Nd-YAG-LASER was used in this study. Papilloma was completely disappeared in four of the six cases. Stenotic changes occurred in two cases and microdochectomy was performed in those patients. The actual energy of 105-928. J.was necessary to treat papilloma. Although there are problems of long treatment time and stenotic change on the ductal surface, this therapy is a valuable method to treat papilloma which could not be cured with non surgical treatment.

导管内乳头状瘤（乳头状瘤）是乳头溢液的主要原因，没有触及肿块。探讨了内镜引导下激光治疗乳头状瘤的方法及其临床应用的可能性。乳头状瘤多生长于乳头附近的输乳管，直径小于2.0cm。此外，许多乳头状瘤在乳管造影上表现为充盈缺损，在内窥镜检查上表现为半球形结节。激光治疗的适应症如下：1）乳头附近乳管造影上的孤立性充盈缺损或充盈缺损中断，2）纤维乳管镜检查上的半球结节，3）管刮匙细胞学结果为良性。在知情同意激光治疗后，进行了激光治疗。激光治疗装置为：直径为0.65mm或0.75mm的内窥镜，通过内窥镜的空气通道引入外径为0.20mm的激光光纤。本研究使用Nd-YAG激光。6例中4例乳头状瘤完全消失。2例出现狭窄改变，行微导管切除术。105-928的实际能量。J.是治疗乳头状瘤所必需的。虽然存在治疗时间长、导管表面狭窄等问题，但对于非手术治疗不能治愈的乳头状瘤，该方法不失为一种有价值的治疗方法。

项目成果

Okazaki, A., et al.: "Nyuukannai bishou byouhen no shintenkeiai kara mita nyuukan naishikyou to nyuukan zouei no shindanteki igi" Jap.J.Breast Cancer. 10 (in japanese). 282-283 (1995)

冈崎 A. 等人：“Nyuukannai bishou byouhen no shintenkeiai kara mita nyuukan naishikyou to nyuukan zouei no shindanteki igi”Jap.J.乳腺癌。

岡崎 稔,岡崎 亮他.: "画像診断のポイント:乳管内視鏡のポイントI." Mamma. 20. 18-19 (1994)

Minoru Okazaki、Ryo Okazaki 等：“图像诊断的要点：乳腺导管内窥镜检查的要点 I” 20. 18-19 (1994)。

岡崎亮他.: "乳管内視鏡所見からみた内視鏡下微小検体採取法の診断的意義" 乳癌の臨床. 10. 676-677 (1995)

Ryo Okazaki 等人：“从乳腺导管内窥镜检查结果的角度来看内窥镜显微标本采集方法的诊断意义”乳腺癌临床。 10. 676-677 (1995)

Okazaki, A., et al.: "Nyuukan naishikyou no jissen" Rinsho Geka. 49 (In Japanese). 33-40 (1994)

冈崎 A. 等人：《Nyuukan naishikyou no jissen》Rinsho Geka。

Okazaki, A., et al.: "Nyuukannai ryousei shuyou ni taisuru nyuukan nai LASER shousha" J.Therap. 76 (in japanese). 187-189 (1994)

Okazaki, A., et al.：“Nyuukannai ryousei shuyou ni taisuru nyuukan nai LASER shousha”J.Therap。