Dynamic studies on the human thalamocortical relation involved in the intractactable functional disorders of the brain

难治性脑功能障碍中人体丘脑皮质关系的动态研究

• 批准号: 06671374
• 负责人: HIRATO Masafumi
• 金额: $ 1.28万
• 依托单位: Gunma University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1994
• 资助国家: 日本
• 起止时间: 1994 至 1995
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-06671374/
• 关键词: Depth microrecording; PET scan; Gamma knife; Thalamic pain; Rigidity; Tremor; Thalamocortical tract; Cortical sensorimotor area; depth microrecording; central(thalamic) pain; rigidity; tremor; dopa induced dyskinesia; thalamocortical tract

(1) In the central pain patients with mild destruction of the thalamic sensory nuclei, electrophysiological study showed that the receptive field of sensory (mainly kinesthetic) responses to peripheral natural stimulation was different from standard thalamic topography in the VIM nucleus. Multiple or convergent responses were sometimes recognized in this nucleus. Irregular burst discharges were often encountered in the thalamic sensory nuclei. In those with definite thalamic damage, irregular burst discharges were often detected around CVD lesion in the thalamic sensory nuclei. Decreased activity with abnormal burst discharges in these nuclei was associated with changes of cortical activity adjacent to the central sulcus (motor, premotor area) in this group. Regional cerebral glucose metabolism (rCMRGlu) and relative ratio of rCMRGlu to oxygen metabolism increased on these cortical areas. It was important for ameliorating the central pain to inhibit these various abnormal neuronal acti … More vities occurred in and around the CVD lesion in the thalamic sensory nuclei. Gamma knife thalamotomy resulted in encouraging outcomes.(2) In rigid type and dopa-induced dyskinesia (DID) type Parkinson's disease (PD), when DID occurred after administration of L-Dopa, the glucose metabolism decreased in the lenticular nucleus but increased in the frontal cortex. Functional mapping study using rCBF revealed that these changes occurred within the premotor or prefrontal area in the frontal lobe. Electrophysiological study showed high frequency and amplitude spontaneous neuronal acitivities occurred in the medial segment of the globus pallidus (GP). In cases with hemitremor type PD,electrophysiological study generally showed that rhythmic burst discharges, being time-locked with peripheral tremor, were recorded in the physiologically identified thalamic VIM.PET study revealed spot-shaped increased zone of rCMRGlu and similar oval-shaped increased zone of rCBF in the primary cortical sensori-motor area on the contralateral side of tremor. This increased zone of rCBF was similar with that of rCBF image during the sequential opposite finger movement. Conversely, reducing tremor by hand manipulation caused decrease of rCBF in this rostral area.(3) Measurement of neurotransmitter using microdialysis was performed in the basal ganglia and the thalamus with normal or experimental tremor monkey. Less

(1)在丘脑感觉核团轻度破坏的中枢性疼痛患者中，电生理研究表明，Vim核对外周自然刺激的感觉（主要是动觉）反应的感受野不同于标准的丘脑地形图。在这个核团中，有时会出现多重或聚合反应。丘脑感觉核团常出现不规则爆发性放电。在明确的丘脑损害中，常在丘脑感觉核团CVD损害周围检测到不规则爆发放电。这些核团的异常爆发性放电活动减少与该组中央沟（运动区，运动前区）附近的皮质活动变化有关。局部脑葡萄糖代谢（rCMRGlu）和rCMRGlu与氧代谢的相对比率增加这些皮质区。抑制这些异常的神经元活动对改善中枢性疼痛有重要意义。 ...更多信息 在丘脑感觉核团的CVD病变内和周围发生了活动。伽玛刀丘脑切开术结果令人鼓舞。(2)在强直型和多巴诱发运动障碍（DID）型帕金森病（PD）中，当给予L-多巴后发生DID时，豆状核的葡萄糖代谢降低，而额叶皮质的葡萄糖代谢增加。使用rCBF的功能映射研究表明，这些变化发生在额叶的运动前区或前额叶区。电生理研究显示苍白球内侧段出现高频、高幅的自发神经元活动。在偏侧震颤型PD患者中，电生理学研究显示丘脑Vim内记录到与外周震颤时间锁定的节律性爆发性放电，PET研究显示震颤对侧初级皮质感觉运动区的rCMRGlu点状增加带和类似椭圆形的rCBF增加带。rCBF的这一增高区与顺序对指运动时的rCBF图像相似。相反，通过手动操作减少震颤导致该吻侧区域的rCBF降低。(3)应用微透析技术对正常和实验性震颤猴的基底节和丘脑进行了神经递质的测定。少

项目成果

M.Hirato: "Use of frameless isocentric stereotactic system(NEURO-SAT) combined with the intra-operative microrecording." Stereotact Funct Neurosurg. 62/63(in press). (1994)

M.Hirato：“使用无框架等中心立体定向系统（NEURO-SAT）结合术中微记录。”

M. Hirato: "The possible role of the cerebral cortex adjacent to the central sulcus for the genesis of contral (thalamic) pain-a metabolic study." Acta Neurochir (Wien). 58 (sup). 141-144 (1993)

M. Hirato：“邻近中央沟的大脑皮层对于控制（丘脑）疼痛的发生可能发挥的作用——一项代谢研究。”

M.Hirato, C.Ohye: "Treatment and diagnosis of Parkinson's disease 2.Advancement of surgical treatment a) Stereotactic Neurosurgery" Clinical Neurosci.12. 1044-1047 (1994)

M.Hirato、C.Ohye：“帕金森病的治疗和诊断 2. 手术治疗的进展 a) 立体定向神经外科”临床神经科学.12。

M.Hirato: "Pathophysiology of central(thalamic) pain:combined change of sensory thalamus with cerebral cortex around central sulcus." Stereotact Funct Neurosurg. 62/63(in press). (1994)

M.Hirato：“中枢（丘脑）疼痛的病理生理学：感觉丘脑与中央沟周围大脑皮层的联合变化。”

M. Hirato: "Surgical treatment for central (thalamic) pain" Funct Neurosurg. 33. 30-37 (1994)

M. Hirato：“中枢（丘脑）疼痛的手术治疗”Funct Neurosurg。