Cerebral blood volume computation using single PET scan data with sequentially administrated 15O2 and H215O

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PET with 15O-labeled tracers is capable of providing crucial information in patients with cerebro-vascular disorders. DBFM method, allowing an extremely shortened examination period of <10 min scan time, was developed for CBF, OEF and CMRO2. The method misses CBV due to elimination of C15O scan. This study was intended to develop a improved technique for CBV. Validity was tested by comparing CBV values in normal (n=43) and patient subjects (n=45). The obtained CBV values in normal subject was 0.041+/-0.023 and in patient was 0.036+/-0.014, those were not significantly different to the conventional method. Regional contrast showed tight correlation, i.e., r=0.90 for normal and r=0.91 for patient. The obtained images were similar between the methods. The present method is of use to assess CBV.