Radiosensitizing effects of a new photosensitizer ATX-S10

新型光敏剂ATX-S10的放射增敏作用

• 批准号: 06671393
• 负责人: ISOBE Naoyuki
• 金额: $ 0.96万
• 依托单位: HIROSHIMA UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1994
• 资助国家: 日本
• 起止时间: 1994 至 1995
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-06671393/
• 关键词: ATX-S10; Radiosensitizer; Brain edema; Malignant brain tumor; 光化学療法; 光感受性物質

Radiosensitizing effects of a new photosensitizer ATX-S101. Intracranial and systemic distribution of ATX-S10 in malignant brain tumor modelThe intracranial and systemic distribution of a new photosensitizer, four-formyloximeetylidene-3-hydroxyl-2-vinyl-deuterio-porphynyl (IX) -6-2-bisaspartic acid (ATX-S10) in experimental rat brain tumor model (9L gliosarcoma) were investigated with emphasis on the distribution in the peritumoral edematous region, and compared it with concentration on tumor, normal brain and serum. The results were as follows.1. The accumulation of ATX-S10 on tumor was very high, while that on peritumoral edematous region was relatively low and that on normal brain was extremely low.2. The accumulation of ATX-S10 on serum was higher than that on tumor.On the basis of this result of its intracranial distribution, we propose the usefulness of ATX-S10 for the photodynamic treatment of malignant brain tumors.2. Radiosensitizing effects of ATX-S10The in vitro and in vivo investigations showed no radiosensitizing effects. As a result, ATX-S10 has no radiosensitizing effects for the treatment for malignant brain tumors.

新型光敏剂ATX-S101的放射增敏作用研究了新型光敏剂four-formyloximeetylidene-3-hydroxyl-2-vinyl-deuterio-porphynyl(IX)-6-2-双天冬氨酸(ATX-S10)在实验性大鼠脑肿瘤模型(9L胶质肉瘤)体内的分布，重点研究了ATX-S10在瘤周水肿区的分布，并与肿瘤、正常脑和血清中的药物浓度进行了比较。研究结果如下：1.研究结果。结论：1.ATX-S10在肿瘤组织中的积聚很高，而在瘤周水肿区的积聚相对较低，在正常脑组织中的积聚极低。ATX-S10在血清中的蓄积量高于在肿瘤上的蓄积量，根据其在脑内的分布情况，我们提出ATX-S10在光动力学治疗恶性脑肿瘤中的应用。ATX-S100的放射增敏作用体外和体内实验均未发现放射增敏作用。因此，ATX-S10对恶性脑肿瘤的治疗没有放射增敏作用。

项目成果

Naoyuki Isobe: "Autitumor Effect of Combination Chemotherapy with TNP-470 and CDDP on Intracranial Tumor Transplanted in Rats. -Histological Changes of Intratumoral Tissue-" Biotherapy. 9. 440-441 (1995)

Naoyuki Isobe：“TNP-470 和 CDDP 联合化疗对大鼠颅内移植肿瘤的自体肿瘤作用。-肿瘤内组织的组织学变化-”生物疗法。

門田秀二: "光感受性物質「ATX-S10」の悪性脳腫瘍モデルにおける脳内および全身への分布動態の検討" 広島大学医学雑誌. 43. 77-85 (1995)

Shuji Kadota：“在恶性脑肿瘤模型中检查光敏剂“ATX-S10”在大脑和全身的分布动态”广岛大学医学杂志 43. 77-85 (1995)。

Shuji Mouden: "Intracranial and Systemic Distribution of New Photo sensitizer ATX-S10 in Malignant Brain Tumor Model." Hirdai ishi. 43. 77-85 (1995)

Shuji Mouden：“新型光敏剂 ATX-S10 在恶性脑肿瘤模型中的颅内和全身分布。”

Naoyuki Isobe: "Antitumor Effect of TNP-470 on Glioma Transplanted in Rats." Biotherapy. 8. 478-479 (1994)

Naoyuki Isobe：“TNP-470 对大鼠神经胶质瘤移植的抗肿瘤作用。”

門田秀二: "水溶性Pheophorbide-aの実験脳腫瘍モデルにおける分布動態の検討-特に腫瘍部と脳浮腫部の比較について-" 第14回 日本レーザー医学会大会 大会論文集. 14. 329-332 (1994)

Shuji Kadota：“实验性脑肿瘤模型中水溶性脱镁叶绿酸-a 分布动态的研究 - 特别是肿瘤区域和脑水肿区域之间的比较 -”日本激光医学会第 14 届年会论文集 14。 329-332（1994）