Study on relationship between the surface amorphous layr of the articular cartilage and pathogenesis of osteoarthrosis

[不稳定兔膝关节关节软骨和软骨下骨表面无定形层变化的研究]兔右膝关节前交叉韧带和内侧副韧带切断2周后，表层变得不规则，局部缺乏暴露下的胶原原纤维网络。软骨内藏红素-o染色强度降低，形成细胞团，关节周围滑膜组织开始替代软骨。在1.5个月时，软骨的消化从浅层向深层发展，在一些地方产生裂缝和溃疡。从这一点开始，软骨下骨的增殖在骨形态计量学中变得有统计学意义。在3个月和6个月观察退行性改变的进展情况。在这个实验性骨关节病模型中，软骨的变化，包括表层的变化在2周时变得明显，而chan…从术后1.5个月开始软骨下骨中的Ge明显增多。[兔膝关节关节面刮伤后关节软骨变化的研究]兔膝关节关节面刮伤2周后，软骨表面层缺失，下层胶原网络暴露。番红-O染色强度减弱，胶原网络开始消化，关节周围滑膜组织开始替代软骨。在1.5个月时，软骨的退化消化进展，减少了组织的厚度，并在一些地方造成溃疡。在3个月、6个月和1年时观察退行性改变的进展。在这项研究中，发现关节软骨在刮擦关节表面后发生进行性退行性改变。这一发现与之前报道的部分厚度软骨缺损缺乏有效修复或进行性退变的研究结果相反。这种差异可能是由于表面损伤的程度不同造成的，本研究比以前的研究更广泛。较少

[Study on Changes in the Surface Amorphous Layr of the Articular Cartilage and in the Subchondral Bone in the Unstable Rabbit Knee Joint] Two weeks after sectioning the anterior cruciate ligament and the medial collateral ligament in the right knee joint of a rabbit, the surface layr became irregular and, in places, deficient exposing the underlying collagen fibril network. Intensity of safranin-o staining in the cartilage decreased, cell clusters were formed, and the periarticular synovial tissue started replacing the cartilage. At 1.5 months, digestion of the cartilage progressed from the superficial zone to the deep zone, creating fissures and ulcers in places. From this point on, proliferation of the subchondral bone became statisti-cally significant in bone morphometry. Progression of the degenerative change with time was observed at 3 and 6 months. In this experi-mental osteoarthrosis model, chondral change including that in the surface layr became apparent at 2 weeks, while chan … More ge in the subcho-dral bone became significant from 1.5 months after surgery on.[Study on Changes in the Articular Cartilage After Scraping the Articular Surface of the Rabbit Knee Joint] Two weeks after scraping of the articular surface of a rabbit knee joint, the surface layr of the cartilage was deficient and the underlying collagen network was exposed. Intensity of safranin-O staining decreased, digestion of the collagen network started in the superficial zone, and the periarticular synovial tissue started replacing the cartilage. At 1.5 months, degenerative digestion of the cartilage progressed decreasing the thickness of the tissue and creating ulcers in places. Progression of the degenerative change with time was observed at 3 and 6 months, and at 1 year. In this study, progressive degenerative change in the articular cartilage was found after scraping of the articular surface. This finding is contrary to results of previous studies reporting the absence of effective repair or progressive degeneration in partial-thickness cartilage defects. The discrepancy may come from difference in the extent of the superficial injury which was wider in the present study than in the previous ones. Less