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Study on relationship between the surface amorphous layr of the articular cartilage and pathogenesis of osteoarthrosis

关节软骨表面非晶层与骨关节病发病机制关系的研究

基本信息

批准号：
06671450
负责人：
KOBAYASHI Seneki
金额：
$ 1.34万
依托单位：
Shinshu University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1994
资助国家：
日本
起止时间：
1994 至 1995
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-06671450/
关键词：
Articular cartilage Surface layr Osteoarthrosis Rabbit Subchondral bone Experimental osteoarthrosis

项目摘要

[Study on Changes in the Surface Amorphous Layr of the Articular Cartilage and in the Subchondral Bone in the Unstable Rabbit Knee Joint] Two weeks after sectioning the anterior cruciate ligament and the medial collateral ligament in the right knee joint of a rabbit, the surface layr became irregular and, in places, deficient exposing the underlying collagen fibril network. Intensity of safranin-o staining in the cartilage decreased, cell clusters were formed, and the periarticular synovial tissue started replacing the cartilage. At 1.5 months, digestion of the cartilage progressed from the superficial zone to the deep zone, creating fissures and ulcers in places. From this point on, proliferation of the subchondral bone became statisti-cally significant in bone morphometry. Progression of the degenerative change with time was observed at 3 and 6 months. In this experi-mental osteoarthrosis model, chondral change including that in the surface layr became apparent at 2 weeks, while chan … More ge in the subcho-dral bone became significant from 1.5 months after surgery on.[Study on Changes in the Articular Cartilage After Scraping the Articular Surface of the Rabbit Knee Joint] Two weeks after scraping of the articular surface of a rabbit knee joint, the surface layr of the cartilage was deficient and the underlying collagen network was exposed. Intensity of safranin-O staining decreased, digestion of the collagen network started in the superficial zone, and the periarticular synovial tissue started replacing the cartilage. At 1.5 months, degenerative digestion of the cartilage progressed decreasing the thickness of the tissue and creating ulcers in places. Progression of the degenerative change with time was observed at 3 and 6 months, and at 1 year. In this study, progressive degenerative change in the articular cartilage was found after scraping of the articular surface. This finding is contrary to results of previous studies reporting the absence of effective repair or progressive degeneration in partial-thickness cartilage defects. The discrepancy may come from difference in the extent of the superficial injury which was wider in the present study than in the previous ones. Less

[兔膝关节不稳定时关节软骨表面无定形层和软骨下骨变化的研究]在兔右膝关节中，在切断前交叉韧带和内侧副韧带两周后，表面层变得不规则，并且在某些地方，缺乏暴露下面的胶原纤维网络。软骨中番红-o染色强度降低，细胞簇形成，关节周围滑膜组织开始取代软骨。在1.5个月时，软骨的消化从浅表区进展到深部区，在某些地方产生裂缝和溃疡。从这一点开始，软骨下骨的增殖在骨形态计量学上变得具有统计学意义。在3个月和6个月时观察到退行性变化随时间的进展。在本实验性骨关节病模型中，包括表层在内的软骨改变在2周时开始明显， ...更多信息从术后1.5个月开始，软骨下骨中的ge显著增加。[刮擦兔膝关节关节面后关节软骨的变化的研究]刮擦兔膝关节的关节面后2周，软骨的表层缺乏并且下面的胶原网络暴露。番红-O染色强度降低，浅表区胶原网络开始消化，关节周围滑膜组织开始取代软骨。在1.5个月时，软骨的退化性消化进展，降低了组织的厚度，并在某些地方产生溃疡。在3个月和6个月以及1年时观察到退行性变化随时间的进展。在这项研究中，在关节面刮擦后，发现关节软骨发生了进行性退行性变化。这一发现与以前的研究结果相反，这些研究报告了部分厚度软骨缺损缺乏有效修复或进行性退化。这种差异可能是由于浅表损伤程度不同，本研究中的浅表损伤程度较以往研究更广。少