The effect of TNF- alpha on the fibroblast of proliferative scar

肿瘤坏死因子 (TNF-α) 或恶病素已被认为是许多宿主对损伤和感染的不良反应的介质。研究表明，在烧伤急性期，烧伤患者血清中的 TNF 升高。此外，这些升高的水平会导致此类患者的伤口愈合延迟。在这项研究中，我们评估了烧伤患者以及疤痕疙瘩和肥厚性疤痕患者的血清 TNF-α 水平，以确定这些患者体内这种介质的水平是否持续升高，从而导致伤口愈合受损。我们的结果表明，重度烧伤患者的 TNF-α 显着升高，直至受伤后 5 年。这可能是导致这些患者感染率增加和伤口愈合延迟的一个因素。目前，我们正在前瞻性地研究 TNF 水平和疤痕形成，因为 TNF 和疤痕之间似乎存在阴阳关系。研究表明，低浓度的 TNF 有助于伤口愈合，而较高浓度可能有害。

Tumor Necrosis Factor (TNF-alpha) or Cachectin has been implcated as a mediator of many of the adverse host responses to injury and infection. TNF has been shown to be elevated in the serum of burn patients during the acute phase of burn injury. Also, the level of these elevations contributes to delayd wound healing in such patients. In this study we evaluated the serum TNF-alpha levels of burn patients and the patients of keloid and hypertrophic scar to ascertain whether elevated levels of this mediator persists in these patients, leading to compromised wound healing.Our results indicate that TNF-alpha is significantly elevated in patients with major burns, up to 5 years after the injury. This may pose a contributing factor towards the increased rate of infections and delayd wound healing seen in these patients. We are presently, prospectively looking at TNF levels and scar formation, as there seems to be a yin-yang relationship between TNF and scarring. Studies suggest that TNF in low concentrations helps wound healing, whereas higher concentrations may be detrimental.