Fund a mental research for treatment of keloid and hypertrophic scar

资助治疗疤痕疙瘩和增生性疤痕的心理研究

• 批准号: 16591805
• 负责人: UEDA Koichi
• 金额: $ 0.96万
• 依托单位: Osaka Medical College
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2004
• 资助国家: 日本
• 起止时间: 2004 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-16591805/
• 关键词: keloid; hypertrophic scar; immunohistochemistry; VEGF; 虚血

We have previously shown that the adenosine triphosphate (ATP) content of keloids remains high for a long time. In keloids, anaerobic glycolysis may be related to the production of ATP. In this study, we counted the vessels in keloids, hypertrophic and atrophic scars in a defined area, and measured the cross-sectional areas of their internal lumens immunohistopathologically and the lactate concentrations. The mean number in a defined area was smallest in keloids as was the mean internal area of vessels. The decreased and narrowed vessels may reduce oxygen perfusion. The blood supply to keloids is inadequate, and this persists.

我们以前已经表明，瘢痕疙瘩的三磷酸腺苷（ATP）含量长期保持较高水平。在瘢痕疙瘩中，无氧糖酵解可能与ATP的产生有关。在这项研究中，我们计数血管瘢痕疙瘩，增生性和萎缩性瘢痕在一个定义的区域，并测量其内腔的横截面积免疫组织病理学和乳酸浓度。瘢痕疙瘩中定义区域的平均数量最小，血管的平均内部面积也最小。减少和狭窄的血管可能减少氧灌注。瘢痕疙瘩的血液供应不足，这仍然存在。

项目成果

Inadequate blood supply persists in keloids

• DOI: 10.1080/02844310410029552
• 发表时间: 2004-11-01
• 期刊: SCANDINAVIAN JOURNAL OF PLASTIC AND RECONSTRUCTIVE SURGERY AND HAND SURGERY
• 作者: Ueda, K;Yasuda, Y;Oba, S
• 通讯作者: Oba, S