The investigation of side dffects to the fingertips caused by dental adhesive monomers.

为了在牙本质和复合材料之间获得完全的边缘适应，牙本质引物被用作粘合剂。然而，即使牙医戴上橡胶手套来保护他或她的手指不受甲基丙烯酸酯的伤害，手指上也经常会出现红肿、肿胀、水泡和瘙痒。本研究的目的是研究这些引物是否会引起接触性皮炎，并通过最大化试验确定20-HEMA、GM和甲基丙烯酸（MA）在豚鼠中致敏和激发的最佳浓度。我们还观察了接触性皮炎的发展在人类臂膀在一个封闭的贴片试验。致敏浓度为0.2%的HEMA导致了强烈的红肿反应和几个囊泡丘疹的发展。敏化浓度为0.5% GM， 24小时后产生强烈的红润反应。

To obtain complete marginal adaptation between the dentin and the composite, dentin primers are used as adhesives. However, even if the dentist tries to protect his or her fingers from the methacrylates by wearing rubber gloves, rubefaction, tumefaction, blebs and pruritus often occur on the fingertips. The purpose of this study was to examine whether these primers cause contact dermatitis and, using a maximization test, to determine the optimum concentrations of 20-HEMA, GM and methacrylic acid (MA) for sensitization and challenge in guinea pigs. We also observed the development of contact dermatitis on human brachia in a closed-patch test. A sensitizing concentration of 0.2% HEMA resulted in the development of strong rubefaction and several vesiculopapules in response to the challenge. A sensitizing concentration of 0.5% GM produced strong rubefaction at 24 hours.