Anticaries Efficacy of <Phytic Acid-Stannous Fluoride> Primer

<植酸-氟化亚锡>底漆的防龋功效

• 批准号: 06671974
• 负责人: HIRABAYASHI Shigeru
• 金额: $ 1.15万
• 依托单位: Tsurumi University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1994
• 资助国家: 日本
• 起止时间: 1994 至 1995
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-06671974/
• 关键词: Anticaries efficacy; Remineralization; Tooth conditioner; Primer; Phytic acid; Stannous fluoride; フッ化錫

The <Phytic acid (PYA)-Stannous Fluoride (SnF_2)> primer has been developed in our department as a tooth conditioner for bonding dental adhesives to tooth substrates. The treatment with this primer requires two steps, a first treatment with 7% aqueous solution of PYA and a second treatment with 3% aqueous solution of SnF_2. Therefore, it is expected that the caries resistance of teeth treated with SnF_2 at second step is improved. This primer is called 7PYA+SnF_2 primer. In this study, the effect of SnF_2 on the remineralization process of enamel treated with 7PYA+SnF_2 primer was investigated by comparing with the other treatments commonly used in dentistry.The tooth conditioners tested were a 10% and a 40% aqueous solution of phosphoric acid, an aqueous solution containing 10% citric acid and 3% FeCl_3,7PYA+SnF_2 primer, and a 7% aqueous solution of PYA as its control. The bovine enamel treated with each tooth conditioner was stored in the remineralization solution prepared according … More to the prescription of ten Cate et al for seven days. The remineralization process of tretaed enamel was evaluated by Knoop hardness (KHN) measurment and SEM observation. The KHNs of enamel treated with conditioners were down to ab.25-40% of that of sound enamel. However, the KHNs were recovered to ab.60-70% after 1 day storage in the remineralization solution in all treatments except 7PYA+SnF_2 primer and did not increase remakably after that. The formation of crystals like hydroxyapatite was found on these enamel surfaces after 1 day storage by SEM observation. On the other hand, the KHN of enamel treated with 7PYA+SnF_2 primer was recovered to ab 30-40% only after seven days. However, the acid-proof layr, which could not be dissolved even with 0.05-N hydrochloric acid and had ab. 5mum in thickness, was found on its surface by SEM observation. This layr also was found immediately after the treatment with 7PYA+SnF_2 primer, but not found in the other treatment. These results suggested that the acid-proof layr controlled the formation of hydroxyapatite, and the 7PYA+SnF_2 primer had an anticaries efficacy. Less

植酸（PYA）-氟化亚锡（SnF_2）底漆是我科研制的一种牙齿调理剂，用于将牙科粘合剂粘结到牙齿基质上。该底漆的处理分两步进行，第一步用7%PYA水溶液处理，第二步用3%SnF_2水溶液处理。因此，预期第二步用SnF_2处理的牙齿的抗龋性得到改善。该引物称为7 PYA +SnF_2引物。本研究以10%和40%磷酸水溶液、10%柠檬酸和3%FeCl_3水溶液、7 PYA + SnF_2底漆、7 7%的PYA水溶液作为对照。将用每种牙齿调理剂处理的牛牙釉质储存在根据本发明制备的再矿化溶液中。 ...更多信息 凯特等人开的十瓶七天的药通过努氏硬度（KHN）测定和扫描电镜观察，评价处理后牙釉质的矿化过程。用调理剂处理的牙釉质的KHN下降到健康牙釉质的约25 -40%。除7 PYA +SnF_2引物处理外，其余处理的KHN在中性化液中保存1天后，恢复到60 -70%，此后KHN的含量没有明显增加。扫描电镜观察发现，在储存1天后，这些釉质表面上形成类似羟基磷灰石的晶体。而7 PYA +SnF_2处理的釉质，其KHN在7天后才恢复到30-40%。而耐酸层用0.05-N盐酸也不溶解，具有良好的耐酸性。5 μ m厚，通过扫描电镜观察发现其表面有一层纳米晶。在7 PYA +SnF_2引物处理后，也立即发现了这一层，而在另一种引物处理中未发现这一层。结果表明，防酸层控制了羟基磷灰石的形成，7 PYA +SnF_2防龋剂具有一定的防龋效果。少

项目成果

Shigeru Hirabayashi: "Influences of various tooth conditioners on the remineralization of enamel in vitro -Evaluation by KHN and SEM observation-" J J Dent Mater. Vol.16 Special 29. 54 (1997)

Shigeru Hirabayashi：“各种牙齿调理剂对体外牙釉质再矿化的影响 - 通过 KHN 和 SEM 观察进行评估 -” J J Dent Mater。

平林茂: "in vitroにおける酸処理エナメル質の再石灰化に及ぼす各種前処理剤の影響-ヌープ硬さとSEM観察による評価-" 歯科材料・器械. 16(S29). 54 (1997)

Shigeru Hirabayashi：“各种预处理剂对酸处理牙釉质体外再矿化的影响 - 通过努普硬度和 SEM 观察进行评估 -”牙科材料和仪器 16（S29）。