Development of antimicrobial denture base resin with antibacterial denatured apatites

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The denture plaque control is an important problem in a society composed largely of elderly people. Therefore, to develop antimicrobial denture base resins, the experimental resins in which were added two apatite-based antibacterial agents were prepared and their antimicrobaial effects were investigated. The influences of addition of antibacterial agents on the physical properties of experimental resins were also examined.A silicate-containing apatite (Si-HAp : Ube Materials) and a silver-sintering apatite (Ag-HAp : Sangi) were used as antibacterial agent. These were added in a commercial denture base resin (Acron Clear : GC) in the range of 3 〜 5 mass%. The durability of antimicobial effects to Candida albicans, flexural strength and color stability of them were examined with aging in water from 0 to 6 months.The antimicrobial effects of experimental resins were maintained in all experimental groups even at 6 months after immersion in water, although its effect was higher for the resin with Ag-HAp than for the resin with Si-HAp. The flexural strengths of experimental resins decreased about 5〜10 % as compared with that of non-added resin, but there was no significant difference in the elastic modulus and flexural deflection between experimental resins and non-added resin. These flexural properties of experimental resins did not decrease significantly after 6 months in water. The color difference (ΔE^*ab) of experimental resin after 6 months in water to before immersion was about 2.5 for the resins with Ag-HAp and about 4.3 for the resins with Si-HAp. These values were negligible because transparent resin was used as the base resin. From these results, it was suggested that the experimental resins could use in clinical application.