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Development of antimicrobial denture base resin with antibacterial denatured apatites

抗菌变性磷灰石抗菌义齿基托树脂的研制

基本信息

批准号：
12671911
负责人：
HIRABAYASHI Shigeru
金额：
$ 2.24万
依托单位：
Tsurumi University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2000
资助国家：
日本
起止时间：
2000 至 2001
项目状态：
已结题

项目摘要

The denture plaque control is an important problem in a society composed largely of elderly people. Therefore, to develop antimicrobial denture base resins, the experimental resins in which were added two apatite-based antibacterial agents were prepared and their antimicrobaial effects were investigated. The influences of addition of antibacterial agents on the physical properties of experimental resins were also examined.A silicate-containing apatite (Si-HAp : Ube Materials) and a silver-sintering apatite (Ag-HAp : Sangi) were used as antibacterial agent. These were added in a commercial denture base resin (Acron Clear : GC) in the range of 3 〜 5 mass%. The durability of antimicobial effects to Candida albicans, flexural strength and color stability of them were examined with aging in water from 0 to 6 months.The antimicrobial effects of experimental resins were maintained in all experimental groups even at 6 months after immersion in water, although its effect was higher for the resin with Ag-HAp than for the resin with Si-HAp. The flexural strengths of experimental resins decreased about 5〜10 % as compared with that of non-added resin, but there was no significant difference in the elastic modulus and flexural deflection between experimental resins and non-added resin. These flexural properties of experimental resins did not decrease significantly after 6 months in water. The color difference (ΔE^*ab) of experimental resin after 6 months in water to before immersion was about 2.5 for the resins with Ag-HAp and about 4.3 for the resins with Si-HAp. These values were negligible because transparent resin was used as the base resin. From these results, it was suggested that the experimental resins could use in clinical application.

在一个以老年人为主的社会中，义齿菌斑的控制是一个重要的问题。因此，为了开发抗菌义齿基托树脂，制备了添加两种磷灰石类抗菌剂的实验树脂，并对其抗菌效果进行了研究。考察了抗菌剂的加入对实验树脂物理性能的影响。采用含硅磷灰石（Si-HAp: Ube Materials）和银烧结磷灰石（Ag-HAp: Sangi）作为抗菌剂。这些被添加到商业义齿基树脂（Acron Clear: GC）中，质量%为3 ~ 5。在水中陈化0 ~ 6个月，考察其对白色念珠菌的抗菌效果持久性、抗弯强度和颜色稳定性。在所有实验组中，即使在水中浸泡6个月后，实验树脂的抗菌效果仍保持不变，尽管Ag-HAp树脂的效果高于Si-HAp树脂。与未添加树脂相比，实验树脂的抗弯强度降低约5 ~ 10%，但弹性模量和弯曲挠度与未添加树脂无显著差异。实验树脂在水中6个月后，这些弯曲性能没有明显下降。Ag-HAp树脂浸泡6个月后与浸泡前的色差（ΔE^*ab）为2.5左右，Si-HAp树脂为4.3左右。这些值可以忽略不计，因为透明树脂被用作基础树脂。结果表明，该树脂具有较好的临床应用价值。