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Is there the risk of lung cancer in dental staff?

牙科工作人员有患肺癌的风险吗？

基本信息

批准号：
06672077
负责人：
NISHIKAWA Tetsunari
金额：
$ 1.28万
依托单位：
Osaka Dental University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1994
资助国家：
日本
起止时间：
1994 至 1995
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-06672077/
关键词：
Dentist Dental technician Lung cancer Lung disease Hair Dental metals Chromium Gold 歯科医療従事者クロムコバルト

项目摘要

In the present study, we assessed the risk of lung cancer in dental staff by measuring the amounts of various metals deposited in the lung tissue of a dental staff. At the autopsy of a dental technician who died of lung cancer, lung tissue samples were excised. The amounts of various metals deposited were determined by thermal neutron radioactive analysis. For two other patients who died of lung cancer and three patients who died of heart disease, various metals were quantitated in the same manner as mentioned above. The results were compared with those from the dental technician. The dental technician's lung tissue proved to have a higher content of the metals Au, Ag, Co, Cr and Cu in comparison with the other patients. These metals are used in dental alloys in considerable quantities, and Au, Cr are considered to be allergenic, and Cr is also carcinogenic. Therefore, we suggest potential adverse pulmonary effects of these metals.In order to investigate the risk and histopathological … More characteristic of lung cancer on pertaining to the dental occupaition, we searched kinds of malignant tumors in a total of 4,138 cases of patients who were diagnosed to be carrying malignant tumor at Osaka Medical Center for Cnacer and Cardiovascular Diseases, of whom 24 were dental staff personnels. 41.7% of dental staff personnels and 19.7% of nondental staff personnels were diagnosed to be carrying the malignant tumor which was identified to be fo the lung cancer. Four histological typing of lung cancer, squamous cell carcinoma, adenocarcinoma, large cell carcinoma and small cell carcinoma were observed in 10.0%, 80.0%, 0.0% and 10.0% respectively out of 10 dental staff personnels and 35.3%, 36.3%, 5.8% and 18.0% respectively out of all 812 patients. We suppose that people engaged in the dental occupation have a high risk of developing lung cancer and its histological typeis highly likely to be of adenocarcinoma.We measured the amounts of various metals deposited in the hair of a dental staff. The amounts of various metals deposited in these sumples were determined by thermal neutron radioactive analysis. The results were compared with those from the deantl staff. The dental staff's hair proved to have a higher content of the metals Al, Au, Co, Cu and V.Our results may suggest that there is the risk of lung cancer in dental staff. Therefor, it might be urged that environmental standards be improved in dental clinics and laboratories. Less

在本研究中，我们通过测量牙科工作人员肺组织中沉积的各种金属的量来评估牙科工作人员患肺癌的风险。在对一名死于肺癌的牙科技师进行尸检时，切除了肺组织样本。沉积的各种金属的量通过热中子放射性分析测定。对于另外两名死于肺癌的患者和三名死于心脏病的患者，以与上述相同的方式对各种金属进行定量。结果与牙科技师的结果进行了比较。与其他患者相比，牙科技师的肺组织中金属Au、Ag、Co、Cr和Cu的含量较高。这些金属在牙科合金中的使用量相当大，而Au、Cr被认为是致敏的，Cr也是致癌的。因此，我们认为这些金属可能对肺部产生不良影响。 ...更多信息为了解肺癌与牙科职业相关的特点，我们对大坂心血管疾病医疗中心诊断为恶性肿瘤的4,138例患者进行了各种恶性肿瘤的调查，其中24例为牙科工作人员。41.7%的口腔科人员和19.7%的非口腔科人员被诊断为恶性肿瘤，并被确定为肺癌。10名口腔科医务人员中肺癌、鳞癌、腺癌、大细胞癌和小细胞癌四种组织学类型的检出率分别为10.0%、80.0%、0.0%和10.0%; 812例患者中肺癌、鳞癌、腺癌、大细胞癌和小细胞癌四种组织学类型的检出率分别为35.3%、36.3%、5.8%和18.0%。我们假设从事牙科职业的人患肺癌的危险性很高，其组织学类型很可能是腺癌，我们测量了牙科工作人员头发中各种金属的沉积量。沉积在这些样品中的各种金属的量由热中子放射性分析确定。并与系主任的调查结果进行比较。牙科工作人员头发中Al、Au、Co、Cu、V等金属元素含量较高，提示牙科工作人员存在患肺癌的危险。因此，它可能是敦促提高环境标准，在牙科诊所和实验室。少