Is there the risk of lung cancer in dental staff?

在本研究中，我们通过测量沉积在牙科工作人员肺组织中的各种金属的数量来评估牙科工作人员患肺癌的风险。在一名死于肺癌的牙科技师的尸检中，肺组织样本被切除。用热中子放射性分析方法测定了各种金属的沉积量。对于另外两名死于肺癌的病人和三名死于心脏病的病人，用上述同样的方法对各种金属进行了定量。结果与牙科技师的结果进行了比较。与其他病人相比，这位牙科技师的肺组织中金、银、钴、铬和铜的含量更高。这些金属被大量用于牙科合金中，金、铬被认为会引起过敏，而铬也会致癌。因此，我们认为这些金属对肺部有潜在的不良影响。为了探讨肺癌的发病风险及与牙科职业有关的组织病理学特征，我们对在大阪癌症心血管疾病医疗中心诊断为恶性肿瘤的4138例患者进行了恶性肿瘤种类的调查，其中24例为牙科工作人员。41.7%的牙科工作人员和19.7%的非牙科工作人员被诊断患有恶性肿瘤，并被确定为肺癌。10名牙科工作人员中肺癌、鳞状细胞癌、腺癌、大细胞癌和小细胞癌的组织学分型分别为10.0%、80.0%、0.0%和10.0%，812例患者中肺癌、鳞状细胞癌、大细胞癌和小细胞癌的组织学分型分别为35.3%、36.3%、5.8%和18.0%。我们认为从事牙科职业的人患肺癌的风险很高，其组织学类型极有可能是腺癌。我们测量了沉积在一名牙医头发中的各种金属的含量。用热中子放射性分析方法测定了样品中各种金属的沉积量。结果与实际工作人员的结果进行了比较。结果表明，牙科工作人员头发中Al、Au、Co、Cu和v的含量较高，提示牙科工作人员存在患肺癌的风险。因此，可以敦促提高牙科诊所和实验室的环境标准。少

In the present study, we assessed the risk of lung cancer in dental staff by measuring the amounts of various metals deposited in the lung tissue of a dental staff. At the autopsy of a dental technician who died of lung cancer, lung tissue samples were excised. The amounts of various metals deposited were determined by thermal neutron radioactive analysis. For two other patients who died of lung cancer and three patients who died of heart disease, various metals were quantitated in the same manner as mentioned above. The results were compared with those from the dental technician. The dental technician's lung tissue proved to have a higher content of the metals Au, Ag, Co, Cr and Cu in comparison with the other patients. These metals are used in dental alloys in considerable quantities, and Au, Cr are considered to be allergenic, and Cr is also carcinogenic. Therefore, we suggest potential adverse pulmonary effects of these metals.In order to investigate the risk and histopathological … More characteristic of lung cancer on pertaining to the dental occupaition, we searched kinds of malignant tumors in a total of 4,138 cases of patients who were diagnosed to be carrying malignant tumor at Osaka Medical Center for Cnacer and Cardiovascular Diseases, of whom 24 were dental staff personnels. 41.7% of dental staff personnels and 19.7% of nondental staff personnels were diagnosed to be carrying the malignant tumor which was identified to be fo the lung cancer. Four histological typing of lung cancer, squamous cell carcinoma, adenocarcinoma, large cell carcinoma and small cell carcinoma were observed in 10.0%, 80.0%, 0.0% and 10.0% respectively out of 10 dental staff personnels and 35.3%, 36.3%, 5.8% and 18.0% respectively out of all 812 patients. We suppose that people engaged in the dental occupation have a high risk of developing lung cancer and its histological typeis highly likely to be of adenocarcinoma.We measured the amounts of various metals deposited in the hair of a dental staff. The amounts of various metals deposited in these sumples were determined by thermal neutron radioactive analysis. The results were compared with those from the deantl staff. The dental staff's hair proved to have a higher content of the metals Al, Au, Co, Cu and V.Our results may suggest that there is the risk of lung cancer in dental staff. Therefor, it might be urged that environmental standards be improved in dental clinics and laboratories. Less