Characteristics and new bone formation of coral as an ideal sacaffold

珊瑚作为理想支架的特征和新骨形成

• 批准号: 19592273
• 负责人: NISHIKAWA Tetsunari
• 金额: $ 2.83万
• 依托单位: Osaka Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19592273/
• 关键词: 歯科インプラント学; サンゴ; 微細構造; 立体構造; 化学的特性; 組織親和性; 毛細血管形成; 足場材料; 新生骨形成; 歯学; 再生医学; 移植再生医療; 生体機能利用; 歯科医学; 移植・再生医療; 歯槽骨; インプラント

Mechanical strength of coral was 12.4 Mpa. Inside the coral were innumerable tubular structures 100-300 μm in diameter that communicated with the outside, connected to neighboring ducts through pores. The surface of the skeleton was covered with innumerable rounded projections of 60-200 nm were observed. In vitro, formation of capillaries was seen around coral particles. In vivo, a block of coral was implanted into an experimental defect in a canine femur. After 8 weeks, multinucleated giant cells were observed in contact with the coral, and bone augmentation was seen together with new bone formation bordered by osteoblasts in the inner cavities of the coral block.

珊瑚的机械强度为12.4MPa。珊瑚内部有无数直径100-300微米的管状结构，与外界相通，通过孔隙与相邻的管道相连。骨骼表面覆盖着无数60-200 nm的圆形突起。在离体条件下，珊瑚颗粒周围可见毛细血管的形成。在体内，将一块珊瑚植入犬股骨的实验性缺损中。8周后，观察到与珊瑚接触的多核巨细胞，在珊瑚块的内腔中观察到骨增加以及与成骨细胞相邻的新骨形成。