Application of Ultrasound to Drug Therapy ; Transdermal Therapeutic System Using Pulsed Ultrasound

研究了开/关比为1：2、1：4和1：9的脉冲超声（1 MHz）对消炎痛软膏剂经皮吸收的影响。超声能量在0.5-2.5 W cm-2的范围内持续10 - 19 min<-2>，通常用于治疗目的的能量水平，发现开/关脉冲比、强度和应用时间在吲哚美辛的经皮声泳给药系统中起重要作用，1：2脉冲输出超声似乎在改善吲哚美辛的经皮吸收方面是最有效的。在1.0 W cm 2的强度和15 min的施加时间下观察到最高穿透<-2>。通过脉冲输出，可以使用更高强度的超声波而不增加皮肤温度。随着超声强度和时间的增加，皮肤损伤逐渐增加，当在适当的强度和时间使用时，脉冲超声似乎是一种安全的技术，用于增强各种药物分子通过人体皮肤。

The effect of pulsed ultrasound (1 MHz) with on/off ratios of 1 : 2,1 : 4 and 1 : 9 on transdermal absorption of indomethacin from and ointment was studied in rats. Ultrasound energy was supplied for between 10 and 19 min at a range of intensities (0.5-2.5 W cm^<-2>), energy levels commonly used for therapeutic purposes.The on/off pulsed ratio, intensity and the time of application were found to play an important role in the transdermal phonophoretic delivery system of indomethacin ; 1 : 2 pulsed output ultrasound appeared to be the most effective in improving the transdermal absorption of indomethacin. The highest penetration was observed at an intensity of 1.0 W cm^<-2> and time of application of 15min. With pulsed output it is possible to use higher intensities of ultrasound without increasing skin temperature. Progressively more skin damage was noted as the intensity and the time o application of ultrasound increased.When used at a proper intensity and time of application, pulsed ultrasound appears to be a safe technique for enhancing the passage of various drug molecules through human skin.