Monitoring of genotoxicity of river water im high sensitive umu test system

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Genotoxicity of organic chemicals in river water was investigated using a highly sensitive umu test with an O-acetyltranferase-overproducing strain Salmonella typhimurium NM2009. Organic chemicals in river water was sampled by blue rayon hanging method and XAD-2 resin column methods. Locations downstream from wastewater treatment plants showed high SOS-inducing activity in both the absence and the presence of a metabolic activation system, suggesting the occurrence of direct-acting nitroarenes and indirect-acting aminoarenes. The present results demonstrate that a high sensitive umu test using an O-acetyltransferase-overproducing strain is a useful bioassay system for the detection of trace amounts of nitroarenes and aminoarenes in the water environment.