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Activities of cat striatal and cortical neurons associated with orienting movements.

猫纹状体和皮质神经元的活动与定向运动相关。

基本信息

批准号：
06680801
负责人：
OHNO Tadao
金额：
$ 1.41万
依托单位：
University of Tsukuba
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1994
资助国家：
日本
起止时间：
1994 至 1995
项目状态：
已结题

项目摘要

1. In order to understand the neuronal mechanism of the control of orienting movement by the basal ganglia, pattern of activities of caudate neurons associated with a visually-guided eye movement task was analyzed in the alert cat. The majority of sampled neurons, which were supposed to be mostly interneurons, showed activities related to some aspects of the task. Neurons which showed activities related to presentation of visual stimuli were classified into two groups : neurons showing activities related to physical aspects of stimuli and those showing activities related to behavioral meanings of stimuli. Neurons of the former group tended to have selectivity of the position of visual stimuli, while neurons of the latter group did not have clear position selectivity. It is likely that some caudate neurons participate in cognitive processes involved in the orienting movement of the cat.2. Effects of attention on the incidence and latency of the caudate-induced eye movement were investig … More ated. The incidence was less and the latency was longer during attentive fixation of the eye to a visual stimulus than during incidental maintenance of the eye position to the same point. This indicates that cortical activities related to attention exert significant influences over the neuronal machinery responsible for the orienting movement.3. Distribution pattern of cortical neurons projecting to the caudate nucleus was investigated by means of retrograde transport of HRP.Caudal parts of the head of the caudate nucleus, which are effective in inducing eye movements by electrical stimulation, tended to receive abundant afferents from the limbic cortex and caudal regions of the cortex which are supposed to be involved in spatial perception, while rostral parts, which are ineffective, tended to receive afferents from rostral cortical areas related to motor functions.4. It is suggested that the caudate nucleus receives afferents from broad areas of the cortex, integrates a variety of information including that related to cognitive function and forms commands for the orienting movement. Less

1.为了了解基底神经节控制定向运动的神经机制，分析了警戒猫视觉引导眼动任务相关尾状核神经元的活动模式。大多数样本神经元，应该是中间神经元，显示出与任务的某些方面相关的活动。显示与视觉刺激呈现有关的活动的神经元被分为两类：显示与刺激的物理方面有关的活动的神经元和显示与刺激的行为意义有关的活动的神经元。前者的神经元倾向于对视觉刺激的位置有选择性，而后者的神经元没有明显的位置选择性。这可能是因为一些尾状神经元参与了猫的定向运动的认知过程。用…研究注意对尾状核诱发眼动发生率和潜伏期的影响更生气了。在眼睛专注地注视视觉刺激的过程中，发病率较低，潜伏期较长，而不是偶然地将眼睛的位置保持到相同的位置。这表明与注意相关的皮层活动对负责定向运动的神经机制产生了显著的影响。用HRP逆行传递法研究了投射到尾状核的皮质神经元的分布模式。在电刺激诱导眼球运动方面，尾状核头部的尾部部分倾向于接受来自边缘皮质和皮质尾侧区域的丰富传入，而非有效的头端部分倾向于接受与运动功能相关的吻侧皮质区域的传入。结果表明，尾状核接受大脑皮质广泛区域的传入信息，整合了包括认知功能在内的多种信息，形成定向运动的指令。较少