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Survey and bacteriological observation of MRSA infection in laboratory animals

实验动物MRSA感染情况调查及细菌学观察

基本信息

批准号：
06680834
负责人：
URANO Toru
金额：
$ 1.47万
依托单位：
KUMAMOTO UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1994
资助国家：
日本
起止时间：
1994 至 1995
项目状态：
已结题

项目摘要

In recent years, MRSA (methicillin resistant Staphylococcus aureus) infections have become an increasing ploblem in postoperative infected, immunocompromised, or otherwise stressed patients in human medicine. Experimental animal facilities are usually located near hospitals, and researchers in a hospital performing animal experiments have frequent contact with both laboratory animals and patients. I therefore surveyed MRSA contamination in laboratory animals, human beings, and the internal environment of our experimental animal facility. I also examined the bacteriological observation of MRSA infection in laboratory animals.Specimens : (1) Human being : swabs from the nasal cavity of the animal caretakers ; (2) Animals : fresh feces, and swabs from the skin of mice, rats, rabbits, monkeys, dogs, pigs, goats ; (3) Environment : swabs from the racks and floors in breeding rooms.Results : MRSA are negative in all specimens from human beings, animals and the environment. Staphylococcus aureus from the specimens of animals are tested to prepare drug resistant organisms for methicillin of antibiotic. But, MRSA was not prepared. Then, mice inoculated with MRSA from the focus of human beings were examined isolation and bacteriological observation of the organisms. MRSA was detected in adult animals, new born animals, the globes of human being and any environments. The effect of disinfection for MRSA was considered to efficiency the alcohol, quarternary ammonium compound and phenol.

近年来，耐甲氧西林金黄色葡萄球菌(MRSA)感染已成为人类医学中术后感染、免疫功能低下或其他应激患者的一个日益严重的问题。实验动物设施通常位于医院附近，进行动物实验的医院的研究人员经常与实验动物和患者接触。因此，我调查了实验室动物、人类和我们实验动物设施的内部环境中的MRSA污染情况。(1)人：动物饲养员鼻腔拭子；(2)动物：新鲜粪便，小鼠、大鼠、兔、猴、狗、猪、山羊皮肤拭子；(3)环境：饲养室架子和地板拭子。从动物标本中检测金黄色葡萄球菌，以制备对甲氧西林耐药的抗生素。但是，耐甲氧西林金黄色葡萄球菌并没有准备好。然后，从人类疫源地接种MRSA的小鼠进行检测、分离和细菌学观察。在成年动物、新生动物、人类的球体和任何环境中都检测到了MRSA。对MRSA的消毒效果考虑为对酒精、季铵化合物和苯酚的消毒效果。