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The Effect of Environmental and Social Stress on Testicular Function in male Japanese monkeys.

环境和社会压力对雄性日本猴睾丸功能的影响。

基本信息

批准号：
06680830
负责人：
SHIMIZU Keiko
金额：
$ 1.41万
依托单位：
KYOTO UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1994
资助国家：
日本
起止时间：
1994 至 1995
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-06680830/
关键词：
Japanese monkey Male Stress Testosterone Cortisol Testis

项目摘要

Five sexually mature, male Japanese monkeys (Macaca fuscata fuscata), at least 8yrs old were used. They were housed in an each outdoor social group cage with some females at the Primate Research Institute, Kyoto University, Japan. After two weeks of blood sampling, they were isolated from a social group to an indoor air-conditioned individual cage in the mid breeding season. After two weeks these males were returned to their home cages. Blood samples were obtained following both the removal and the return two weeks later. Plasma concentrations of luteinizing hormone (LH), testosterone, cortisol, prolactin, and inhibin were determined by specific radioimmunoassays. Plasma concentrations of testosterone were significantly increased after the isolation, whereas cortisol levels were decreased. Following after return to their home cage, these changes were recovered. The absence of a stress response to separation in adult males is in contrast to the presence of a stress response observed in infants, juveniles, and adult females and possibly is due to the differences of environmental temperature.In the next bleeding season, same monkeys were isolated from a social group to an outdoor individual cage. After two weeks isolation, they were returned to their home cages. Blood samples were obtained in the same manner. Plasma testosterone were significantly increased immediately after both isolation and return, but decreased within the isolation period. In contrast with the previous study, plasma cortisol were elevated immediately after both isolation and return. Plasma LH,prolactin, and inhibin were not changed before and after the isolation. These results showed that the isolation was influenced these males as a stressor. Furthermore, the return to the social group did induce a psychosocial stress response in the males and the degree of the stress.

使用5只性成熟的雄性日本猴（Macaca fuscata fuscata），至少8岁。在日本京都大学灵长类动物研究所，将它们与一些雌性动物一起圈养在每个室外社会群体笼中。在两周的血液采样后，在繁殖季节中期，将它们从社会群体隔离到室内空调个体笼中。两周后，将这些雄性动物放回其饲养笼中。两周后取出和返回后采集血样。通过特异性放射免疫测定法测定促黄体生成素（LH）、睾酮、皮质醇、催乳素和雌二醇的血浆浓度。血浆睾酮浓度显着增加隔离后，而皮质醇水平下降。在返回其饲养笼后，这些变化恢复。在成年雄性中没有分离的应激反应与在婴儿、青少年和成年雌性中观察到的应激反应的存在相反，可能是由于环境温度的差异，在下一个出血季节，将相同的猴子从社会群体隔离到室外个体笼中。隔离两周后，它们被放回笼子里。以相同的方式获得血样。血浆睾酮显着增加后立即隔离和返回，但在隔离期间下降。与以前的研究相比，血浆皮质醇升高后立即隔离和返回。血浆LH，催乳素，和Escherichin没有改变之前和之后的隔离。这些结果表明，孤立作为一种应激源影响这些男性。此外，返回社会群体确实引起了男性的心理社会应激反应和应激程度。