Mouse adenovirus infection in SCID mice

小鼠腺病毒K87(MAV)在普通小鼠肠道内复制，感染3周后，由于肠道局部中和IgA类抗体的作用，在粪便中完全检测不到MAV。在先天性裸鼠中，从粪便中检测到病毒的时间持续到感染后约6周，远远晚于正常小鼠。表现为可检测到的病毒消失的耐药性是暂时的，干扰素、自然杀伤细胞激活和巨噬细胞参与的影响是负面的，尽管环磷酰胺治疗已被证明完全消除了耐药性。MAV感染的严重联合免疫缺陷(SCID)小鼠不产生中和抗体，缺乏功能性T、B细胞，有些小鼠表现出明确的持续性感染，而另一些小鼠则经历病毒复制和抵抗期的反复，与裸鼠的感染过程相似。目前，正在进行的研究正在测试这样一种假设，即支持某些SCID小鼠表现出的对病毒的抵抗力的因素与在裸鼠身上发现的相似。

Mouse adenovirus K87(MAV) replicate within the intestinal tract of ordinary mice, becoming completely undetectable in feces 3 weeks after infection due to the action of localized neutralizing IgA class antibodies in the intestinal tract. In congenitally athymic nude mice, detection of virus from feces continues up to about 6 weeks after infection, far later than in normal mice. The resistance manifested as disappearance of detectable virus is temporary, and implications of interferon, natural killer cell activation, and macrophage involvement are negative, although cyclophosphamide administration has been demonstrated to eliminate the resistance altogether. Neutralizing anti-bodies are not produced in MAV infected severe combined immunodeficiency (SCID) mice, lacking functional T and B cells, and some mice exhibit definite sustained infections, while others undergo repeated periods of viral replication and resistance, similar to the course of infection in nude mice. And presently, studies are underway to test the assumption that the factor upholding the resistance to virus exhibited by some of the SCID mice is akin to that found in nude mice.