Molecular mechanisms of tumorigenesis in primary aldosteronism

原发性醛固酮增多症肿瘤发生的分子机制

• 批准号: 444776998
• 负责人: Professor Dr. Martin Reincke
• 金额: --
• 依托单位: Medizinische Klinik und Poliklinik IV
• 依托单位国家: 德国
• 项目类别: Research Grants
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/444776998?language=en
• 关键词: Molecular; mechanisms; tumorigenesis; primary; aldosteronism

The primary objective of this proposal is to delineate the molecular mechanisms that lead to dysregulated tumor growth of aldosterone-producing adenomas (APAs) using RNA-seq to compare the transcriptional profiles of APAs stratified by nodule diameter and genotype. Secondly, we will investigate the mechanism of tumourigenesis of aldosterone-producing cell cluster to APA transition by metabolite profiling of adrenal lesions in PA using in situ matrix-assisted laser desorption/ionization mass spectrometric imaging (MALDI-MSI). The long term aim of our work is to improve the diagnosis and management of PA in line with the translational research goals of the PA group in Munich.

本研究的主要目的是利用RNA-seq比较按结节直径和基因型分层的醛固酮生成腺瘤（APAs）的转录谱，来描述导致APAs肿瘤生长失调的分子机制。其次，我们将利用原位基质辅助激光解吸/电离质谱成像（MALDI-MSI）对PA中肾上腺病变的代谢物进行分析，研究醛固酮产生细胞簇向APA过渡的肿瘤发生机制。我们工作的长期目标是改善PA的诊断和管理，以符合慕尼黑PA小组的转化研究目标。