Molecular mechanisms of tumorigenesis in primary aldosteronism

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The primary objective of this proposal is to delineate the molecular mechanisms that lead to dysregulated tumor growth of aldosterone-producing adenomas (APAs) using RNA-seq to compare the transcriptional profiles of APAs stratified by nodule diameter and genotype. Secondly, we will investigate the mechanism of tumourigenesis of aldosterone-producing cell cluster to APA transition by metabolite profiling of adrenal lesions in PA using in situ matrix-assisted laser desorption/ionization mass spectrometric imaging (MALDI-MSI). The long term aim of our work is to improve the diagnosis and management of PA in line with the translational research goals of the PA group in Munich.