ぶどう膜炎における血液-房水関門の破綻と一酸化窒素合成酵素の関与について

血-房水屏障的破坏和一氧化氮合酶在葡萄膜炎中的参与

• 批准号: 07671914
• 负责人: 万代 道子
• 金额: $ 1.34万
• 依托单位: Kyoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 无数据
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-07671914/
• 关键词: エンドトキシンぶどう膜炎; リポポリサッカライト; 一酸化窒素合成酵素

平成7年度の研究によって以下の結果を得た.○L-N2Oは生体投与にて誘導型の一酸化窒素合成酵素をL-NNAは生体投与にて常在型の一酸化窒素合成酵素(NOS)をより効果的に抑制した.○LPS投与によるエンドトキシンぶどう膜炎において、L-N2Oは肝組織のNOS誘導型を、L-NNAは常在型を抑制した.○エンドトキシンぶどう膜炎において、L-NNAは細胞の浸潤とたんぱくの前房漏出を著明に抑制した.またその効果は極早期の投与において著しく、6時間後では効果がなかった.○同ぶどう膜炎においてL-N2Oはたんぱく漏出はおさえたが、細胞の浸潤は抑制しなかった.このことからエンドトキシンぶどう膜炎の発症には、ごく早期に常在型NOSが(血管内皮において)関与している可能性が示唆された.

The following results were obtained in the study of Pingcheng in 7 years. The following results were obtained. The results are as follows: the results of the study in 7 years in Pingcheng showed that the following results were obtained in the study of Pingcheng in 7 years. The following results were obtained from the following results of the 7-year study in Pingcheng. The results of the following results were obtained in the study of Pingcheng in 7 years. The results of the following results were found in the following results of the 7-year study in Pingcheng. The results of the following results are as follows. The results of the following results were obtained in the study of Pingcheng in 7 years. The results of the following results were obtained in the study of Pingcheng in 7 years. The results of the following results were obtained in the study of Pingcheng in 7 years. The results of the following results were obtained in the study of Pingcheng. The following results were obtained in the study of Pingcheng in 7 years L-NNA is a common form of inhibition. 0. 0% of the disease is caused by inflammation. The cells of L-NNA are infiltrated. The leakage of the anterior chamber shows inhibition. After 6: 00 am, the results showed that there was no significant difference between the early stage and the early stage of the treatment. 0. 0 after 6: 00 p. M., the L-N2O was leaked, and the cell was immersed to inhibit the leakage of the drug. The symptoms of meningitis, early persistent NOS (vascular endothelial dysfunction), and the possibility of inflammation in the early stage indicate instigation.

项目成果

Michiko Mandai: "Role of Nitric Oxide Synthase Tsozymes in Endotoxin, Induced Uveitis." Investigation Ophthalmology and Visual Science. (発表予定).

Michiko Mandai：“一氧化氮合酶酶在内毒素、诱发葡萄膜炎中的作用”。眼科和视觉科学研究（即将发表）。