Interventional Treatment and Molecular Imaging of Coronary and Myocardial Inflammation by Magnetic Resonance Imaging (C15+ (P15))

冠状动脉和心肌炎症的磁共振成像介入治疗和分子影像（C15（P15））

• 批准号: 444989213
• 金额: --
• 依托单位: Klinik für Kardiologie und Angiologie
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2020
• 资助国家: 德国
• 起止时间: 2019-12-31 至 2023-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/444989213?language=en
• 关键词: Interventional; Treatment; Molecular; Imaging; Coronary

This project aims to develop non-invasive magnetic resonance imaging (MRI) of inflammation with non-myocyte specific molecular imaging contrast agents, intravascular high-resolution MRI of coronary vessel walls, and interventional real-time MRI-guided coronary intervention with implantation of scaffolds or drug eluting stents for sealing of inflamed pla¬ques in a pig model. Furthermore, P15 will characterise downstream myocardial inflammation and its heterocellular interactions after MI, caus¬ed by catheter-based coronary artery occlusion. These tools will be used to explore temporal progression of in vivo lesion dynamics and of res¬ponses to intervention.

该项目旨在利用非肌细胞特异性分子成像造影剂开发炎症的非侵入性磁共振成像（MRI），冠状血管壁的血管内高分辨率MRI，以及在猪模型中植入支架或药物洗脱支架进行介入性实时MRI引导冠状动脉介入治疗，以封闭炎症斑块。此外，P15将表征由导管冠状动脉闭塞引起的心肌梗死后下游心肌炎症及其异细胞相互作用。这些工具将用于探索体内病变动态的时间进展和对干预的反应。