Interventional Treatment and Molecular Imaging of Coronary and Myocardial Inflammation by Magnetic Resonance Imaging (C15+ (P15))

冠状动脉和心肌炎症的磁共振成像介入治疗和分子影像（C15（P15））

• 批准号: 444989213
• 金额: --
• 依托单位: Klinik für Kardiologie und Angiologie
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2020
• 资助国家: 德国
• 起止时间: 2019-12-31 至 2023-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/444989213?language=en
• 关键词: Interventional; Treatment; Molecular; Imaging; Coronary

This project aims to develop non-invasive magnetic resonance imaging (MRI) of inflammation with non-myocyte specific molecular imaging contrast agents, intravascular high-resolution MRI of coronary vessel walls, and interventional real-time MRI-guided coronary intervention with implantation of scaffolds or drug eluting stents for sealing of inflamed pla¬ques in a pig model. Furthermore, P15 will characterise downstream myocardial inflammation and its heterocellular interactions after MI, caus¬ed by catheter-based coronary artery occlusion. These tools will be used to explore temporal progression of in vivo lesion dynamics and of res¬ponses to intervention.

This project aims to develop non-invasive magnetic resonance imaging (MRI) of inflammation with non-myocyte specific molecular imaging contrast agents, intravascular high-resolution MRI of coronary vessel walls, and interventional real-time MRI-guided coronary intervention with implantation of scaffolds or drug eluting stents for sealing of inflamed pla¬ques in a pig model.此外，p15将表征下游心肌感染及其在MI之后由基于导管的冠状动脉闭塞引起的MI后的杂细胞相互作用。这些工具将用于探索体内病变动力学和对干预措施的临时进展。