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Molecular mechanisms and structural determinants of pharmacological chaperone action; therapeutic potential for the treatment of early onset severe obesity

Molecular mechanisms and structural determinants of pharmacological chaperone action; therapeutic potential for the treatment of early onset severe obesity
药理学伴侣作用的分子机制和结构决定因素；
批准号：
478493
负责人：
Bouvier Michel
金额：
$64.09万
依托单位：
Institute for Research in Immunology and Cancer (Montreal, QC)
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2023
资助国家：
加拿大
项目状态：
未结题
起止时间：
2023-03-01 至 2028-03-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=478493&lang=en
关键词：
Conformational Diseases Drug Discovery G Protein-Coupled Receptors Genetic Diseases Inherited Diseases Melanocortin Type 4 Receptor Obesity Pharmacological Chaperones Protein Folding Protein Trafficking

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中文摘要
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英文摘要
Misfolding of proteins resulting from genetic mutations is a frequent cause of inherited diseases known as conformational diseases. Since G protein-coupled receptors (GPCRs) are involved in most physiological functions, mutations of members of this large
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  • 批准号：
    344989
  • 项目类别：
    Operating Grants
  • 资助金额：
    $88.83万
  • 财政年份：
    2016
  • 负责人：
    Bouvier Michel
  • 依托单位：
    Universit de Montral
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