Plasticity of the mitochondrial contact site and cristae organizing complex (A10*)

线粒体形态在不同组织中有显著差异，但这种结构可塑性的功能分支尚不清楚。嵴是线粒体内膜的内陷，是最灵活的结构之一，线粒体接触部位和嵴组织（MICOS）复合物在控制其形状方面起着关键作用。我们将研究MICOS复合体在不同组织中的精确组成和结构及其可塑性的功能后果，以揭示嵴结构与线粒体生理适应的联系机制。

Mitochondrial morphology varies markedly among different tissues, but the functional ramifications of this structural plasticity remain unclear. Cristae, invaginations of the inner mitochondrial membrane, are among the most flexible structures and the mitochondrial contact site and cristae orga¬nizing (MICOS) complex acts as a key player in controlling their shape. We will study the precise composition and structure of the MICOS complex in different tissues and the functional consequence of its plasticity, to shed light on the mechanisms linking cristae structure to physiological adaptations of mitochondria.