Fundamental theoretical and experimental investigations of wavefront shaping deep in biological media

生物介质深层波前整形的基础理论和实验研究

• 批准号: 445978371
• 负责人: Professor Dr. Alwin Kienle
• 金额: --
• 依托单位: Institut für Lasertechnologien in der Medizin und Meßtechnik an der Universität Ulm (ILM)
• 依托单位国家: 德国
• 项目类别: Research Grants
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/445978371?language=en
• 关键词: Fundamental; theoretical; experimental; investigations; wavefront

The aim of the requested project is the fundamental investigation of wavefront shaping deep in scattering, especially biological, media and of its applications based on exact and efficient - both analytical and numerical - solutions of Maxwell's equations and of the radiative transfer equation. For example, the focusing due to wavefront shaping will be characterized systematically regarding all optical properties and the focus depth in the scattering medium both for pulsed and for continuous wave sources. Further, a variety of techniques, for example, correlation studies of the reflected elastically scattered light and the reflected one- and multiphoton fluorescence light, will be investigated to achieve a successful non-invasive feedback about the formation of a sharp focus deep in the scattering medium. The theoretical results will be validated with measurements on optically and geometrically, partly microscopically, accurately characterized static and non-static phantoms and on animalic ex vivo tissue. In case of success, this research work promises a series of very important applications, especially, microscopic imaging of biological tissue much deeper than is possible today.

所要求的项目的目的是基于麦克斯韦方程和辐射传输方程的精确和有效的解析和数值解，对波前整形进行基础性研究，特别是在生物介质中的波前整形及其应用。例如，对于脉冲和连续波源，由于波前整形引起的聚焦将根据所有光学特性和散射介质中的聚焦深度来系统地表征。此外，将研究各种技术，例如，反射弹性散射光与反射的单光子和多光子荧光光的相关性研究，以实现关于散射介质深处形成尖锐焦点的成功的非侵入性反馈。理论结果将通过在光学和几何上、部分在显微镜下、准确地表征静态和非静态模型以及在动物体外组织上的测量来验证。如果成功，这项研究工作将有一系列非常重要的应用，特别是生物组织的显微成像，比今天可能的深度要深得多。