Analysis of the impact of donor tissue characteristics on the outcome of Descemet Membrane Endothelial Keratoplasty (DMEK)

供体组织特征对后弹力层内皮角膜移植术（DMEK）效果的影响分析

• 批准号: 446812117
• 负责人: Dr. Silvia Schrittenlocher
• 金额: --
• 依托单位: Institut für Medizinische Statistik und Bioinformatik
• 依托单位国家: 德国
• 项目类别: Research Grants
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/446812117?language=en
• 关键词: Analysis; impact; donor; tissue; characteristics

The most common form of transplantation in medicine istransplantation of the cornea. This field has been revolutionized in thelast couple of years by introducing a new lamellar cornealtransplantation technique, called DMEK (Descemet MembraneEndothelial Keratoplasty). Hereby, only the inner layer of the cornea,endothelium and its basal membrane, is being selectivelytransplanted in eyes with corneal diseases that only affect thisparticular inner layer. Since this surgical approach is still beingoptimized, large studies are needed to analyze efficacy and safety ofthis technique. Not much is know so far on the impact of donor tissuecharacteristics on DMEK outcome. Therefore, the aim of this project isto extend the largest prospective German DMEK database by adding donor tissue and preparation characteristics and to analyze the role ofthese donor tissue characteristics on the outcome of DMEK surgery.The results of this project will help to further improve this alreadysuccessful corneal transplantation technique.

医学上最常见的移植形式是角膜移植.在过去的几年里，这一领域发生了翻天覆地的变化，推出了一种新的板层角膜移植技术，称为Descemet MembaeEndothelialKeratportion(后膜内皮角膜移植)。因此，只有角膜的内层，即内皮及其基底膜，将被选择性地移植到患有仅影响这一特定内层的角膜疾病的眼睛中。由于该手术入路仍在优化中，需要进行大量研究来分析该技术的有效性和安全性。到目前为止，供体组织特性对DMEK结局的影响还不是很清楚。因此，本项目的目的是通过添加供体组织和制备特征来扩展德国最大的预期DMEK数据库，并分析这些供体组织特征对DMEK手术结果的影响，该项目的结果将有助于进一步改进这一已经成功的角膜移植技术。