Obesity, Metabolic Syndrome, and Lymphatic Dysfunction
肥胖、代谢综合征和淋巴功能障碍
基本信息
- 批准号:10705331
- 负责人:
- 金额:$ 60.12万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-09-22 至 2024-08-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAdipocytesAdipose tissueAdultAffectAttentionBioinformaticsCommunicationCoupledDataDepositionDietDietary FatsDiseaseEvaluationExposure toFluid BalanceHealthHealthcare SystemsHumanImpairmentIn VitroIndividualInflammationInflammatoryInvestigationKnock-outKnowledgeLifeLife StyleLymphLymphangiogenesisLymphaticLymphatic SystemLymphatic functionMediatingMesenteryMetabolicMetabolic dysfunctionMetabolic syndromeMethodsMissionMitochondriaModelingMolecularNon-Insulin-Dependent Diabetes MellitusObesityOrgan DonorOutcomePermeabilityPrevalenceProteinsProteomicsProtocols documentationPublic HealthPumpRNARattusReproducibilityResearchRisk FactorsRodent ModelStressStructureTestingTherapeuticTissuesTranslatingUnited States National Institutes of HealthVisceralWorkZucker Ratsbasecadherin 5cardiometabolic riskdesigndietarydisabilityexperimental studyhuman tissuein vivoinnovationinsightlipid transportlymph flowlymphatic developmentlymphatic dysfunctionlymphatic pumplymphatic vesselmesenteric lymphaticsmouse modelnew growthnovelnovel strategiespreventskillstranscriptomicstranslational impactvirtual
项目摘要
The relationship between mesenteric lymphatic vessels and surrounding visceral adipose of the mesentery has
received increased attention due to observations that imply that dysfunctional lymphatic vessels contribute to
adipose deposition in the mesentery. While there has been much work done in rodent models of obesity and
metabolic syndrome, there is virtually nothing known about how mesenteric lymphatic vessels are altered both
structurally and functionally in humans with metabolic syndrome. To address this important and enormous
knowledge gap, novel protocols to study human mesentery and lymphatic vessels derived from organ donors
with or without metabolic syndrome have been developed and optimized. The rationale for this approach is that
the findings will enable a leap forward in knowledge about the lymphatic-visceral adipose axis that is directly
relevant to humans. The central hypothesis to be tested is that metabolic syndrome impairs lymphatic function
and that impaired mesenteric lymphatics perpetuate metabolic dysfunction. Guided by robust preliminary data,
this hypothesis will be tested in with two specific aims. Specific Aim 1 is to determine mechanisms underlying
lymphatic dysfunction in obesity and metabolic syndrome. Specific Aim 2 is to determine how dysfunctional
lymphatics contribute to metabolic deficits in mesenteric tissue. These aims will utilize mesenteric tissue from
human organ donors, which permits the study of mesenteric lymphatic pump function, permeability, and network
structure. The functional studies will be coupled to transcriptomic and proteomic approaches to identify the RNA
and protein landscapes in the mesenteric adipose depots surrounding lymphatic vessels. In addition, studies of
in vivo lymphatic pumping and permeability in relevant rat and mouse models will help identify causal
mechanisms in the two-way communication between lymphatic vessels and visceral adipose tissue. The
significance of the proposed research is that it will provide the first comprehensive analysis of human mesentery,
including the protein and RNA landscapes, lymphatic vessel networks, lymphatic pump function, and lymphatic
permeability that will produce novel information about how human lymphatic vessels interact with visceral
adipose tissue in the context of metabolic syndrome. The proposed research is innovative because it opens a
new line of investigation focusing on human mesenteric lymphatic structure and function that will provide the first
large-scale evaluation of human mesenteric lymphatic pump function and permeability directly related to human
health and disease.
肠系膜淋巴管与肠系膜周围内脏脂肪的关系
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
JEROME W BRESLIN其他文献
JEROME W BRESLIN的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('JEROME W BRESLIN', 18)}}的其他基金
Microvascular Leakage in Hemorrhagic Shock and Trauma
失血性休克和创伤中的微血管渗漏
- 批准号:
10406620 - 财政年份:2022
- 资助金额:
$ 60.12万 - 项目类别:
Human Resistance Artery Functional Changes with Alcohol Use
饮酒后人体阻力动脉功能的变化
- 批准号:
10372624 - 财政年份:2022
- 资助金额:
$ 60.12万 - 项目类别:
Microvascular Leakage in Hemorrhagic Shock and Trauma
失血性休克和创伤中的微血管渗漏
- 批准号:
10799161 - 财政年份:2022
- 资助金额:
$ 60.12万 - 项目类别:
Microvascular Leakage in Hemorrhagic Shock and Trauma
失血性休克和创伤中的微血管渗漏
- 批准号:
10646258 - 财政年份:2022
- 资助金额:
$ 60.12万 - 项目类别:
Human Resistance Artery Functional Changes with Alcohol Use
饮酒后人体阻力动脉功能的变化
- 批准号:
10589888 - 财政年份:2022
- 资助金额:
$ 60.12万 - 项目类别:
S1P-fluid therapy to reduce hemorrhagic shock & intoxication-induced injury
S1P 液体疗法可减少失血性休克
- 批准号:
9310336 - 财政年份:2016
- 资助金额:
$ 60.12万 - 项目类别:
Regulatory Mechanisms for Resolution of Inflammatory Microvascular Leakage
解决炎症性微血管渗漏的调节机制
- 批准号:
8903501 - 财政年份:2011
- 资助金额:
$ 60.12万 - 项目类别:
Regulatory Mechanisms for Resolution of Inflammatory Microvascular Leakage
解决炎症性微血管渗漏的调节机制
- 批准号:
8183125 - 财政年份:2011
- 资助金额:
$ 60.12万 - 项目类别:
Regulatory Mechanisms for Resolution of Inflammatory Microvascular Leakage
解决炎症性微血管渗漏的调节机制
- 批准号:
8496100 - 财政年份:2011
- 资助金额:
$ 60.12万 - 项目类别:
Regulatory Mechanisms for Resolution of Inflammatory Microvascular Leakage
解决炎症性微血管渗漏的调节机制
- 批准号:
8574448 - 财政年份:2011
- 资助金额:
$ 60.12万 - 项目类别:
相似国自然基金
支链氨基酸代谢紊乱调控“Adipocytes - Macrophages Crosstalk”诱发2型糖尿病脂肪组织功能和结构障碍的作用及机制
- 批准号:81970721
- 批准年份:2019
- 资助金额:55.0 万元
- 项目类别:面上项目
相似海外基金
Recruitment of brown adipocytes in visceral white adipose tissue by fibroblast growth factor 8b
成纤维细胞生长因子 8b 将棕色脂肪细胞募集到内脏白色脂肪组织中
- 批准号:
321208980 - 财政年份:2016
- 资助金额:
$ 60.12万 - 项目类别:
Research Grants
Enhancing Energy Expending Adipocytes in White Adipose Tissue
增强白色脂肪组织中的能量消耗脂肪细胞
- 批准号:
8827438 - 财政年份:2014
- 资助金额:
$ 60.12万 - 项目类别:
Induction of brown-like adipocytes in white adipose tissue by food-derived factors
食物源性因子在白色脂肪组织中诱导棕色样脂肪细胞
- 批准号:
26450168 - 财政年份:2014
- 资助金额:
$ 60.12万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
WAT-on-a-chip - Development of a micofluidic, microphysiologic in vitro adipose tissue model for high-throughput drug screening based on hiPSC-derived adipocytes.
WAT-on-a-chip - 开发微流体、微生理体外脂肪组织模型,用于基于 hiPSC 衍生脂肪细胞的高通量药物筛选。
- 批准号:
257256526 - 财政年份:2014
- 资助金额:
$ 60.12万 - 项目类别:
Research Fellowships
Enhancing Energy Expending Adipocytes in White Adipose Tissue
增强白色脂肪组织中的能量消耗脂肪细胞
- 批准号:
8828181 - 财政年份:2013
- 资助金额:
$ 60.12万 - 项目类别:
Enhancing Energy Expending Adipocytes in White Adipose Tissue
增强白色脂肪组织中的能量消耗脂肪细胞
- 批准号:
8520690 - 财政年份:2013
- 资助金额:
$ 60.12万 - 项目类别:
Enhancing Energy Expending Adipocytes in White Adipose Tissue
增强白色脂肪组织中的能量消耗脂肪细胞
- 批准号:
8629741 - 财政年份:2013
- 资助金额:
$ 60.12万 - 项目类别:
Effect of exercise training on formation of brite adipocytes within white adipose tissue
运动训练对白色脂肪组织内脂肪细胞形成的影响
- 批准号:
23700778 - 财政年份:2011
- 资助金额:
$ 60.12万 - 项目类别:
Grant-in-Aid for Young Scientists (B)
Investigation for the mechanisms of the emergence of brown adipocytes in white adipose tissue
白色脂肪组织中棕色脂肪细胞出现机制的研究
- 批准号:
21780261 - 财政年份:2009
- 资助金额:
$ 60.12万 - 项目类别:
Grant-in-Aid for Young Scientists (B)
LOUISIANA COBRE: P1: INDUCE THERMOGENIC BROWN ADIPOCYTES IN WHITE ADIPOSE TISSUE
路易斯安那 COBRE:P1:在白色脂肪组织中诱导产热棕色脂肪细胞
- 批准号:
7610781 - 财政年份:2007
- 资助金额:
$ 60.12万 - 项目类别: