Mechanisms of infertility induced in mice by vaccination with murine zona pellucida 3

鼠透明带3疫苗接种诱导小鼠不育的机制

• 批准号: DP0559839
• 负责人: Prof Geoffrey Shellam
• 金额: $ 15.26万
• 依托单位: The University of Western Australia
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2005
• 资助国家: 澳大利亚
• 起止时间: 2005-01-01 至 2008-12-22
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0559839
• 关键词: Mechanisms; infertility; induced; mice; vaccination

This research investigates the means by which a novel immunocontraceptive vaccine induces an infertile state in female mice. The vaccine stimulates an autoimmune condition which resembles certain naturally occurring ovarian diseases. By investigating how ovarian cellular interactions are maintained in normal ovaries and disrupted by the immunocontraceptive vaccine, we will learn a great deal about ovarian function in health and disease. Ultimately this information will be applied to improving the reproductive health of women.

本研究探讨了一种新型免疫避孕疫苗诱导雌性小鼠不育的方法。 疫苗刺激自身免疫性疾病，类似于某些自然发生的卵巢疾病。 通过研究卵巢细胞相互作用如何在正常卵巢中维持并被免疫避孕疫苗破坏，我们将了解大量关于健康和疾病中卵巢功能的信息。 这些信息最终将用于改善妇女的生殖健康。