Immune and stromal dysregulation by excess dietary lipids leading to airway hyperresponsiveness (P12)

膳食脂质过多导致免疫和基质失调，导致气道高反应性 (P12)

• 批准号: 448249330
• 金额: --
• 依托单位: Institut für Experimentelle Immunologie
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2021
• 资助国家: 德国
• 起止时间: 2020-12-31 至 2023-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/448249330?language=en
• 关键词: Immune; stromal; dysregulation; excess; dietary

One of the consequences of Western diet is airway hyperreactivity (AH), which manifests itself as obesity-associated asthma. Besides the alteration of macrophages, that have been implicated in AH, we observed lipid accumulation and altered stromal cell composition in the lung. Here, we propose that pulmonary macrophages and stromal cells programmed by the lipid milieu synergize in the development of AH. The project will define these molecular pathways and dissect the contribution of these cells and their crosstalk during AH. The data will identify key mechanisms that drive the disease and will thereby enable potential new targeted therapies for AH.

西方饮食的后果之一是气道高反应性（AH），表现为肥胖相关性哮喘。除了与AH有关的巨噬细胞的改变外，我们还观察到肺中脂质蓄积和基质细胞组成的改变。在这里，我们提出，肺巨噬细胞和基质细胞编程的脂质环境协同发展的AH。该项目将定义这些分子通路，并剖析这些细胞的贡献和它们在AH期间的串扰。这些数据将确定驱动疾病的关键机制，从而为AH提供潜在的新靶向治疗。