Determinants of Expression, Assembly and Function of the Noradrenaline Transporter

去甲肾上腺素转运蛋白表达、组装和功能的决定因素

• 批准号: DP0558018
• 负责人: A/Prof Lesley Bryan-Lluka
• 金额: $ 14.92万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2005
• 资助国家: 澳大利亚
• 起止时间: 2005-01-01 至 2007-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0558018
• 关键词: Determinants; Expression; Assembly; Function; Noradrenaline

The noradrenaline transporter protein that is the focus of this project is important for mental health because it belongs to the family of proteins where psychostimulants, such as cocaine, and drugs used in the treatment of depression act. The project will lead to exciting advances in our understanding of how the structure of this protein controls its functions, and potentially to the design of better antidepressant drugs and to the design of drugs to prevent the effects of cocaine.

去甲肾上腺素转运蛋白是该项目的重点，对心理健康很重要，因为它属于可卡因等精神兴奋剂和治疗抑郁症的药物作用的蛋白质家族。该项目将导致我们对这种蛋白质的结构如何控制其功能的理解取得令人兴奋的进展，并可能设计更好的抗抑郁药物和设计药物来防止可卡因的影响。