Developmental study of the specific prescription program for the improvement of mental health trouble in human

改善人类心理健康问题的具体处方方案的开发研究

• 批准号: 14208005
• 负责人: SHIBAYAMA Hidetaro
• 金额: $ 30.53万
• 依托单位: National Institute of Fitness and Sports in Kanoya
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2005
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14208005/
• 关键词: mental health; stress; exercise prescription; skeletal muscle; autonomic nervous function; brain; positron emission tomography; 疲労; 脳; 糖; 最大酸素摂取量; 乳酸; 情動; 脳活動; エネルギー代謝; 遊離脂肪酸; 扁桃体; 橋網様体; 随意運動; 大脳基底核; 視床; 大脳辺縁系; 精神活動; 循環機能; 脳波; 心拍数

The overall purpose of this study was to obtain experimental evidences to develop a specific prescription program for the people who have a trouble in mental health. We observed the effects of several exercise combined-programs on the brain tissue, cardiovascular systems, autonomic nervous function, and skeletal muscles of human subjects and experimental animals. The main results of the human studies are summarized as follows.We investigated the effects of exercise on myocardial glucose uptake and whether the pattern of glucose uptake is the same as in skeletal muscle. Glucose uptake was measured using positron emission topography (PET) and 2-[^<18>F] fluoro-2-deoxy-D-glucose. As compared to the resting state, exercise doubled myocardial glucose uptake at the 30% and 55% intensity levels, while at the 75% intensity level glucose uptake was reduced significantly compared to the lower exercise intensities. At rest and during low-intensity exercise, myocardial glucose uptake was inversely … More associated with circulating levels of free fatty acids. However, during higher exercise intensities when plasma lactate concentrations increased significantly, this association disappeared. This finding suggests that the increased myocardial energy that is needed during high-intensity exercise is supplied by substrates other than glucose.Reductions in the compliance of central arteries exert a number of adverse effects on systemic cardiovascular function and diseases. Using the cross-sectional study design, we determined the relation between chronic resistance training and carotid arterial compliance. (1)resistance exercise training is associated with the smaller central arterial compliance in health middle-aged men ; (2)age-related reductions in arterial compliance was greater in resistance-trained men than in sedentary men ; (3)the lower arterial compliance in the resistance-trained men is associated with left ventricular hypertrophy. In marked contrast to the beneficial effect of regular aerobic exercise, the present findings are not consistent with the idea that resistance exercise training exerts beneficial influences on arterial wall buffering functions. Less

这项研究的总体目的是获得实验证据，以为在心理健康方面遇到麻烦的人们制定特定的处方计划。我们观察到了几个运动组合程序对人类受试者和实验动物的脑组织，心血管系统，自主神经功能以及骨骼肌的影响。人类研究的主要结果总结如下。我们研究了运动对心肌葡萄糖摄取的影响，以及葡萄糖摄取的模式是否与骨骼肌中相同。使用二极体发射地形（PET）和2 - [^<18> f]氟-2-脱氧-D-葡萄糖测量葡萄糖摄取。与静息状态相比，运动在30％和55％的强度水平上增加了一倍的心肌葡萄糖摄取，而在75％的强度水平下，与较低的运动强度相比，强度水平的摄取量显着降低。在休息和低强度运动中，心肌葡萄糖的吸收成反比……更多与循环的游离脂肪酸水平有关。但是，在血浆乳酸浓度显着升高时，在较高的运动强度期间，这种关联消失了。这一发现表明，在高强度运动过程中需要增加的心肌能量是由葡萄糖以外的其他底物提供的。中央动脉的依从性在依从性中会对全身性心血管功能和疾病产生许多不利影响。使用横断面研究设计，我们确定了慢性抗性训练与颈动脉依从性之间的关系。 （1）抵抗运动训练与卫生中年男性中较小的中央动脉依从性有关； （2）在抗药性训练的男性中，与年龄相关的动脉依从性降低要比久坐的男性更大； （3）受抗性训练的男性的下动脉依从性与左心室肥大有关。与定期有氧运动的有益作用形成鲜明对比，目前的发现与阻力运动训练锻炼对动脉壁缓冲功能有益的影响不一致。较少的

项目成果

Differential contribution of skeletal and cardiac II-III loop sequences to the assembly of DHP-receptor arrays in skeletal muscle.

骨骼和心脏 II-III 环序列对骨骼肌中 DHP 受体阵列组装的差异贡献。

• 发表时间: 2004
• 期刊: Mol.Biol.Cell. 15
• 作者: Takekura;H.;Paoini;C.;Franzini-Armstrong;C.;Kugler;G.;Grabner;M.;Flucher;B.E.
• 通讯作者: B.E.

Fujimoto, T., Kemppainen, J., Kalliokoski, K.K., Nuutila, P., Ito, M.: "Skeletal muscle glucose uptake response to exercise in trained and untrained men."Med.Sci.Sports Exerc.. 35. 777-783 (2003)

Fujimoto, T.、Kemppainen, J.、Kalliokoski, K.K.、Nuutila, P.、Ito, M.：“受过训练和未经训练的男性骨骼肌葡萄糖摄取对运动的反应。”Med.Sci.Sports Exerc.. 35. 777

Fluctuations in carotid arterial distensibility during the menstrual cycle do not influence cardiovagal baroreflex sensitivity.

月经周期期间颈动脉扩张性的波动不影响心脏迷走神经压力反射敏感性。

• 发表时间: 2006
• 期刊: Acta Physiol (Oxf). 186
• 作者: Hayashi;K.;Miyachi;M.;Seno;N.;Takahashi;K.;Yamazaki;K.;Sugawara;J.;Yokoi;T;Onodera;S.;Mesaki;N.
• 通讯作者: N.

藤本敏彦, 伊藤正敏: "非侵襲的手法による筋の糖・脂質代謝と運動"体育の科学. 52. 429-435 (2002)

Toshihiko Fujimoto、Masatoshi Ito：“使用非侵入性方法进行肌肉葡萄糖/脂质代谢和运动”《体育科学》52. 429-435 (2002)。

Dissociation between the time courses of femoral artery blood flow and pulmonary VO2 during repeated bouts of heavy knee extension exercise in humans.

人类重复进行剧烈膝关节伸展运动时，股动脉血流和肺摄氧量的时程之间的关联。

• 发表时间: 2004
• 期刊: Exp.Physiol. 89
• 作者: Fukuba;Y.;Ohe;Y.;Miura;A.;Kitano;A.;Endo;M.;Sato;H.;Miyachi;M.;Koga;S.;Fukuda;O.
• 通讯作者: O.