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Optical-molecular cooperative computing based on parallel optical trapping technique

基于并行光捕获技术的光分子协同计算

基本信息

批准号：
15200023
负责人：
TANIDA Jun
金额：
$ 32.36万
依托单位：
Osaka University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (A)
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2005
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15200023/
关键词：
optical-molecular cooperative computing parallel optical trapping VCSEL array DNA reaction DNA cluster discrete quadratic programming photonic DNA memory DNA computing 最大クリーク問題集合演算光トラップファジィビーズ

项目摘要

This study is aimed at developing optical-molecular cooperative computing techniques, which are based on manipulation of a group of molecules with optical field distributions. The major research targets include devising an effective computing algorithm, establishing a method for manipulating DNA molecules that are attached to microscopic beads by parallel optical trapping, developing a photonic method for DNA reactions within a local space, and demonstrating the usability of these photonic techniques in DNA memory.The result of numerical calculations concerning information density, processing time, and data-transferring rate explains fundamental characteristics of an information system based on optical -molecular cooperative computing. We have created an efficient algorithm for discrete quadratic programming via mathematical analyses and computation with DNA.The parallel optical trapping technique using VCSEL array sources were used for handling the position of groups of DNA molecules … More attached to a bead (a DNA cluster). Experimental results demonstrate that the method is applicable in transferring DNA clusters in parallel by sequential switching of emitting sources without any mechanical movement, and in stacking five DNA clusters. In addition, a photonic method was developed for DNA reactions ; the method utilizes local change of the temperature in a DNA solution induced by photo-thermal conversion. An important achievement is that hybridization and denaturation of DNA on a bead or a substrate are successfully controlled by irradiating with a focused laser beam. The minimum reaction width was measured as 5 micrometer.We proposed photonic DNA memory, in which a system containing hairpin DNA is used and operated by photonic techniques. Experimental results demonstrate that, for example repeating operations of attachment and detachment of data DNA on a bead is possible by appropriate temporal modulation of the power of the irradiation beam. We also succeeded in reading data DNA out from a substrate to a bead locally. Less

本研究的目的是发展光学分子合作计算技术，这是基于操纵一组分子的光场分布。主要研究目标包括设计一种有效的计算算法，建立一种通过平行光阱操纵附着在微珠上的DNA分子的方法，发展一种在局域空间内进行DNA反应的光子方法，并证明这些光子技术在DNA存储器中的可用性。数据传输速率解释了基于光分子协同计算的信息系统的基本特征。通过对DNA的数学分析和计算，提出了一种求解离散二次规划问题的有效算法，并采用VCSEL阵列光源的并行光阱技术处理DNA分子组的位置 ...更多信息附着在珠子上（DNA簇）。实验结果表明，该方法适用于通过顺序切换发射源而无需任何机械运动的DNA团簇的并行转移，以及5个DNA团簇的堆叠。此外，还开发了一种用于DNA反应的光子方法;该方法利用光热转换引起的DNA溶液中温度的局部变化。一个重要的成就是通过用聚焦激光束照射成功地控制了珠或基底上的DNA的杂交和变性。最小反应宽度为5 μ m。我们提出了光子DNA存储器，其中使用了一个含有发夹结构DNA的系统，并通过光子技术进行操作。实验结果表明，例如，通过适当地对照射束的功率进行时间调制，可以重复数据DNA在珠上的附着和脱离操作。我们还成功地将数据DNA从基底局部地阅读到珠上。少