权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Intensive study for realization of the next-generation brain PET system with high sensitivity, high spatial resolution and high speed

深入研究实现高灵敏度、高空间分辨率、高速度的下一代脑部PET系统

基本信息

批准号：
15200043
负责人：
MURAYAMA Hideo
金额：
$ 30.78万
依托单位：
National Institute of Radiological Sciences
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (A)
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2005
项目状态：
已结题

项目摘要

Key technologies to realize the next-generation PET system with high sensitivity, high spatial resolution and high speed has been studied. We have developed growing technology of large gadolinium silicate (GSO) single crystals with a diameter of 100 mm. In our depth-of-interaction (DOI) detector, we can control the behavior of scintillation photons by inserting the reflector between crystal elements. The determination of the crystal of the interaction is performed on a two-dimensional histogram mapped by Anger-type positioning arithmetic calculation with output signals from PS-PMT optically coupled to the crystal array. A high-performance brain DOI-PET scanner, jPET-D4, has been developed at NIRS. This scanner was designed to achieve not only high spatial resolution but also high sensitivity using four-layered DOI detectors. The scanner has five detector rings with the ring diameter of 390mm and each detector ring consists of 24 DOI detectors. Each DOI detector consists of 1,024 GSO crystals, which are arranged in four layers of 16 x 16 arrays, coupled to a 52 mm square 256ch position sensitive PMT (FP-PMT). The crystal elements are 2.9 x 2.9 x 7.5 mm^3. The crystals of layer-1, 2 and layer-3, 4 are GSO doped with 0.5 mol% and 1.5 mol% Ce, respectively. The sensitivity at the center of FOV is 112 kcps/MBq and spatial resolution is less than 3 mm all over the FOV.

研究了实现下一代高灵敏度、高空间分辨率和高速PET系统的关键技术。我们开发了直径为100 mm的大尺寸硅酸钆（GSO）单晶的生长技术。在我们的相互作用深度（DOI）探测器中，我们可以通过在晶体元件之间插入反射器来控制闪烁光子的行为。相互作用的晶体的确定是在二维直方图上进行的，该二维直方图是通过利用来自光耦合到晶体阵列的PS-PMT的输出信号进行Anger型定位算术计算而绘制的。NIRS开发了高性能脑DOI-PET扫描仪jPET-D4。该扫描仪的设计不仅实现了高空间分辨率，而且使用四层DOI探测器实现了高灵敏度。扫描仪有5个探测器环，环直径为390 mm，每个探测器环由24个DOI探测器组成。每个DOI探测器由1，024个GSO晶体组成，这些晶体排列在四层16 x 16阵列中，耦合到52平方毫米的256通道位置敏感PMT（FP-PMT）。晶体元件的尺寸为2.9 x 2.9 x 7.5 mm^3。层1、2和层3、4的晶体分别是掺杂有0.5摩尔%和1.5摩尔% Ce的GSO。视场中心的灵敏度为112 kcps/MBq，整个视场的空间分辨率小于3 mm。