Development of new methods for risk assessment on multi-chemical exposure to human fetus

开发人类胎儿多种化学品暴露风险评估新方法

基本信息

  • 批准号:
    17201013
  • 负责人:
  • 金额:
    $ 32.78万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for Scientific Research (A)
  • 财政年份:
    2005
  • 资助国家:
    日本
  • 起止时间:
    2005 至 2007
  • 项目状态:
    已结题

项目摘要

1. Analysis of gene expression and assessment of exposure level of environmental chemicals of umbilical cord: To investigate association of gene expression and exposure level of umbilical cord, five pair s of twin were used. It is found that maternal body, one of the environmental factors, affected gene expression. When human umbilical vein smooth muscle cells (HUVSMC) were exposed to polychlorinated biphenyls (coplanar PCBs: PCB77 and PCB126, non-coplanar PCBs: PCB153) and 3-methylcholanthrene (3MC, one of the dioxin-like compound), eNOS, NPPB, and IL-6 were down regulated by DNA microarray and real-time PCR. Because these genes involved blood vessel construction, it may be affected to fetal development.2. Because it is thought that chemicals affect to epigenetics of DNA, we investigated on Dmnts, DNA methylation enzymes by in situ hybridization and immunohistochemistry.3. To know current situation of PCB exposure of Japanese, we analyzed blood PCB levels of 406 people including infants. PCB levels of infant with breast milk were higher than without breast milk. Adult PCB levels increased as age. PCB was indicator as chlorinated chemicals.4. To investigate association of chemical exposure in utero and allergy, we constructed follow up system using bank system of umbilical cord.
1.基因表达分析与脐带环境化学品暴露水平评估:为探讨基因表达与脐带暴露水平的关系,选取5对双胞胎进行研究。研究发现,母体作为环境因素之一,影响基因表达。DNA微阵列和实时荧光定量PCR技术检测人脐静脉平滑肌细胞(HUVSMC)暴露于多氯联苯(PCB 77和PCB 126,PCB 153)和3-甲基胆蒽(3 MC,二恶英类化合物)后,eNOS、NPPB和IL-6表达下调。由于这些基因参与血管的构建,可能影响胎儿的发育.鉴于化学物质对DNA表观遗传学的影响,我们采用原位杂交和荧光化学方法对Dmnt、DNA甲基化酶进行了研究.为了解日本人多氯联苯(PCB)暴露现状,对406名日本人(包括婴幼儿)的血液PCB水平进行了分析。母乳喂养的婴儿PCB水平高于非母乳喂养的婴儿。成人PCB水平随年龄增长而增加。多氯联苯作为氯化物的指示物.为探讨宫内化学品暴露与变态反应的关系,我们利用脐带库系统建立了随访系统。

项目成果

期刊论文数量(125)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Association of increased type I collagen expression and relative stromal overgrowth in mouse epididymis neonatally exposed to diethylstilbestrol
  • DOI:
    10.1002/mrd.20347
  • 发表时间:
    2005-11
  • 期刊:
  • 影响因子:
    2.5
  • 作者:
    K. Yamazaki;H. Fukata;T. Adachi;H. Tainaka;Masao Kohda;M. Yamazaki;K. Kojima;K. Chiba;C. Mori;M. Komiyama
  • 通讯作者:
    K. Yamazaki;H. Fukata;T. Adachi;H. Tainaka;Masao Kohda;M. Yamazaki;K. Kojima;K. Chiba;C. Mori;M. Komiyama
Environmental health and medical school
环境健康与医学院
  • DOI:
  • 发表时间:
    2006
  • 期刊:
  • 影响因子:
    0
  • 作者:
    藤田 祐生;et. al.;E. Todaka and H. Nakaoka;Y Matsuno
  • 通讯作者:
    Y Matsuno
Relationship between IgE level and exposure to formaldehyde during gross anatomy laboratory course
大体解剖实验课程中 IgE 水平与甲醛暴露之间的关系
  • DOI:
  • 发表时间:
    2006
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Y. Matsuno;K. Ohmichi;F. Nomura and C. Mori
  • 通讯作者:
    F. Nomura and C. Mori
The establishment of environmental preventive medicine to protect future generations, using the data of PCBs in human blood
利用人体血液中 PCB 的数据建立保护子孙后代的环境预防医学
  • DOI:
  • 发表时间:
    2006
  • 期刊:
  • 影响因子:
    0
  • 作者:
    E. Todaka;N. Omori and C. Mori.
  • 通讯作者:
    N. Omori and C. Mori.
Measurement of total PCBs concentration is useful for exposure assessment of dioxins in human
总 PCB 浓度的测量有助于评估人体二恶英的暴露情况
  • DOI:
  • 发表时间:
    2005
  • 期刊:
  • 影响因子:
    0
  • 作者:
    E. Todaka;H. Fukata;K. Sakurai;T. Jotaki;Y. Nakatomi;Y. Kawashiro;N. Omori;M. Omori-Inoue and C. Mori
  • 通讯作者:
    M. Omori-Inoue and C. Mori
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MORI Chisato其他文献

MORI Chisato的其他文献

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{{ truncateString('MORI Chisato', 18)}}的其他基金

Use of maternal blood and the umbilical cord for the assessment of fetal exposure to multiple chemicals: implications for future generations
使用母血和脐带评估胎儿接触多种化学物质的情况:对后代的影响
  • 批准号:
    24310021
  • 财政年份:
    2012
  • 资助金额:
    $ 32.78万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Study of DNA methylation and gene expression during development of male reproductive organs. -Global analysis of DNA methylation using Restriction Landmark Genomic Scanning (RLGS) method-
男性生殖器官发育过程中DNA甲基化和基因表达的研究。
  • 批准号:
    14370004
  • 财政年份:
    2002
  • 资助金额:
    $ 32.78万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Studies on adverse effects of endocrine disruptors on male reproduction and next generation.
内分泌干​​扰物对男性生殖及下一代不良影响的研究。
  • 批准号:
    11839013
  • 财政年份:
    1999
  • 资助金额:
    $ 32.78万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Analysis of spermatogenesis & meiosis using knockout mice
精子发生分析
  • 批准号:
    09670010
  • 财政年份:
    1997
  • 资助金额:
    $ 32.78万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Apoptosis and epithelium-mesenchyme interaction during mammalian morphogenesis
哺乳动物形态发生过程中的细胞凋亡和上皮间质相互作用
  • 批准号:
    07670012
  • 财政年份:
    1995
  • 资助金额:
    $ 32.78万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Spermatogenic cell specific gene expression in mammals : Enzymes of glycolysis
哺乳动物生精细胞特异性基因表达:糖酵解酶
  • 批准号:
    05670008
  • 财政年份:
    1993
  • 资助金额:
    $ 32.78万
  • 项目类别:
    Grant-in-Aid for General Scientific Research (C)

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研究核受体和重复序列以揭示环境化学物质对产前神经系统影响的基础
  • 批准号:
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