Population based study of genetic risk and gene-environment interaction in lifestyle-related diseases including coronary artery diseases(KING Study)

包括冠状动脉疾病在内的生活方式相关疾病的遗传风险和基因-环境相互作用的人群研究（KING 研究）

• 批准号: 17209021
• 负责人: YOKOTA Mitsuhiro
• 金额: $ 28.12万
• 依托单位: Aichi Gakuin University (2006-2007)Nagoya University (2005)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17209021/
• 关键词: Investigation of Genetic Risk of Cardiovascular Di; King Study; Cohort Study; Lifestyle Related-Disease; Genome-Wide and Candidate Gene Association Study; Odds Ratio; Susceptibility Gene; DNA Bank; 心筋梗塞; KING study; 症例-対照関連解

Atherosclerotic CAD is a major health problem around the world. The CAD is believed to be multifactorial and to result from many genes, each with a relatively small effect, working alone or in combination with modifier genes and/or environmental factors.Despite the years of research, the genetic basis of CAD or myocardial infarction (MI) remains to be fully elucidated. In this paper, we highlight emerging knowledge and paradigms from a number of technologies to identify susceptibility genes to MI.The coronary artery disease (CAD) results from the combination of multiple genetic and environmental factors. We describe the genetic approaches researchers are using to advance understanding and preventing of CAD. The genetic identification of the future development of risk factors will lead to genome-informed tailored prevention

动脉粥样硬化性冠心病是世界范围内的一个主要健康问题。冠心病被认为是多因素的结果，每个基因的影响相对较小，单独或与修饰基因和/或环境因素联合作用。尽管多年来的研究，CAD或心肌梗死(MI)的遗传学基础仍未完全阐明。在这篇文章中，我们重点介绍了从一些技术中识别MI易感基因的新兴知识和范例。冠状动脉疾病(CAD)是多种遗传和环境因素共同作用的结果。我们描述了研究人员正在使用的遗传方法来促进对CAD的理解和预防。对危险因素未来发展的遗传识别将导致基因组信息量身定做的预防

项目成果

Myocardial 1231-MIBG scintigraphy reflects left ventricular functional reserve in patients with nonobstructive hypertrophic cardiomyopathy

心肌1231-MIBG闪烁扫描反映非梗阻性肥厚型心肌病患者左心室储备功能

• 发表时间: 2005
• 期刊: Journal of the American College of Cardiology 46
• 作者: Morita Y.;et al.;Satoshi Isobe
• 通讯作者: Satoshi Isobe

Mechanisms of the inhibitory effect of Epigal locatechin α3βallate on cultured human vascular smooth muscle cell invasion.

Epigallocatechinα3βallate对培养的人血管平滑肌细胞侵袭的抑制作用机制。

• 发表时间: 2005
• 期刊: Arteriosclerosis, Thrombosis, and Vascular Biology 25
• 作者: Imai N;Hishikawa K;Marumo T;Hirahashi J;Inowa T;Matsuzaki Y;Okano H;Kitamura T;SalantD;Fujita T;Xian Wu Cheng
• 通讯作者: Xian Wu Cheng

Hypertension : Basic and clinical : Long-term Nifedipine attenuates myocardial collagen remodeling and prevents diastolic dysfunction through antioxidative stress in Dahl salt-sensitive hypertensive rats.

高血压：基础和临床：长期服用硝苯地平可减弱达尔盐敏感性高血压大鼠的心肌胶原重塑，并通过抗氧化应激预防舒张功能障碍。

• 发表时间: 2007
• 作者: Furuta C;dt al.;Takashi Yamada
• 通讯作者: Takashi Yamada

The distal protection during primary percutaneous coronary intervention alleviates the adverse effects of large thrombus burden on myocardial reperfusion

初次经皮冠状动脉介入治疗时的远端保护减轻大血栓负荷对心肌再灌注的不利影响

• 发表时间: 2007
• 期刊: Circulation Journal 70
• 作者: Hisashi Umeda

Prediction of the genetic risk of coronary artery disease from polymorphisms in candidate genes.

从候选基因的多态性预测冠状动脉疾病的遗传风险。

• 发表时间: 2005
• 期刊: Japanese Heart Journal 44 supple.
• 作者: Sahoko Ichihara;Mitsuhiro Yokota
• 通讯作者: Mitsuhiro Yokota