Clarification of retrotransposition mechanisms of target-specific LINE

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We have studied molecular mechanisms of retrotransposition of non-LTR retrotransposon, so called LINE, which is the most major elements in chromosomes of higher organisms such as human, using target specific LINEs. In this project, we have succeeded in clarifying the mechanisms of how the translation of LINE proteins is regulated, how ribonucleoprotein (RNP) complex of proteins and mRNA of LINEs are constructed, and how the complex approach to the target sequences in chromosomes, which are novel mechanisms peculiar to LINE.