Chemical Biology of DNA Structure and Functions
Chemical Biology of DNA Structure and Functions
批准号:
19205023
负责人:
SUGIYAMA Hiroshi
金额:
$26.96万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (A)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2010
中文摘要
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英文摘要
Our research group are utilizing photo-irradiation of BrU substituted DNA to investigate the DNA structure and reactivity relationship at a molecular level. These studies demonstrated the detailed relationships between the local DNA structures and the photochemical products of photoinduced hydrogen abstraction by the resulting uracil-5-yl radicals, and proposed that this photochemical method can be used to detect DNA structures. Dynamic DNA conformational change which directly relates to specific gene expression can chemically be understood.
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Alkylation of a Human Telomere Sequence by Heterotrimeric Chlorambucil PI Polyamide Conjugates.
通过异三聚苯丁酸氮芥 PI 聚酰胺缀合物对人端粒序列进行烷基化。
DOI:
--
发表时间:
2010
期刊:
Bioorg.Med.Chem. 18
影响因子:
--
作者:
[Kashiwazaki, G., Bando, T., Shinohara, K., Mioshima, M., Kumamoto, H., Nishijima, S., Sugiyama, H.]
通讯作者:
H.
ウィーバー分子生物学第4版
韦弗分子生物学第四版
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[R. F. Weaver著, 杉山弘監訳]
通讯作者:
杉山弘監訳
研究業績・論文リスト参照
查看研究成果和论文列表
DOI:
--
发表时间:
期刊:
影响因子:
--
作者:
[]
通讯作者:
光で核酸の構造と物性を観る
用光观察核酸的结构和物理性质
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[長嶋剣, 森内善伸, 田中今日子, 塚本勝男, 杉山弘]
通讯作者:
杉山弘
DNA Alkylation by Pyrrole-Imidazole seco-CBI Conjugates with an Indole Linker : Sequence-Specific DNA Alkylation with Ten-Base-Pair Recognition throug Hetelodimer Formation.
吡咯-咪唑 seco-CBI 与吲哚接头缀合进行的 DNA 烷基化:通过异二聚体形成进行十碱基对识别的序列特异性 DNA 烷基化。
DOI:
--
发表时间:
2007
期刊:
J.Am.Chem.Soc. 129
影响因子:
--
作者:
[Minoshima, M., Bando, T., Sasaki, S., Shinohara, K., Shimizu, T., Fujimoto, J., Sugiyama, H.]
通讯作者:
H.
共 49 条
Overseas Expansion and Internal Labor Markets of Companies in Prewar Japan: An Empirical Analysis of the Sugar Industry in Colonial Taiwan Utilizing Employee Records
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批准号:15K03594
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.25万
-
财政年份:2015
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负责人:SUGIYAMA Hiroshi
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依托单位:
Control and elucidation of gene expression at a molecular level
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批准号:24225005
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项目类别:Grant-in-Aid for Scientific Research (S)
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资助金额:$136.2万
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财政年份:2012
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负责人:SUGIYAMA Hiroshi
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依托单位:
The study of medieval hidtory and production of ceramics in Cambodia
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批准号:19900125
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项目类别:
-
资助金额:$0.0万
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财政年份:2007
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负责人:SUGIYAMA Hiroshi
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依托单位:
Chemical biology based determination of DNA local structures in vivo
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批准号:17201043
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$17.72万
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财政年份:2005
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负责人:SUGIYAMA Hiroshi
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依托单位:
Tailor-made Antitumor Agents based on DNA Sequence
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批准号:17016033
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项目类别:Grant-in-Aid for Scientific Research on Priority Areas
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资助金额:$30.02万
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财政年份:2005
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负责人:SUGIYAMA Hiroshi
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依托单位:
Photochemical probe of DNA local structures
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批准号:15201046
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$17.8万
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财政年份:2003
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负责人:SUGIYAMA Hiroshi
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依托单位:
Sequence-Specific Alkylating Agent as A Novel Type of Antitumor Agent
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批准号:12358011
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$16.76万
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财政年份:2000
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负责人:SUGIYAMA Hiroshi
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依托单位:
Collaboration on DNA sequence-specific recognition by small molecules
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批准号:10044134
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项目类别:Grant-in-Aid for Scientific Research (B).
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资助金额:$6.72万
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财政年份:1998
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负责人:SUGIYAMA Hiroshi
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依托单位:
Design of Gene Therapeutic Agent Possessing Cooperative DNA Alkylating Ability
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批准号:09555283
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$7.1万
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财政年份:1997
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负责人:SUGIYAMA Hiroshi
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依托单位:
Synthesis of Puromycin Tethered RNA and It's Application for Molecular Evolution
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批准号:09480139
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$7.23万
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财政年份:1997
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负责人:SUGIYAMA Hiroshi
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依托单位:
Probing DNA local structure by photoirradiation and application toward gene therapy.
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批准号:07458143
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$4.42万
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财政年份:1995
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负责人:SUGIYAMA Hiroshi
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依托单位:
PRODUCTION AND DISTRIBUTION IN ANCIENT BRONZE MIRRORS
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批准号:06610385
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.22万
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财政年份:1994
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负责人:SUGIYAMA Hiroshi
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依托单位:
Probing DNA Structure by Photoelectron Transter and Its Application toward Gene The rapy
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批准号:05680524
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.28万
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财政年份:1993
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负责人:SUGIYAMA Hiroshi
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依托单位:
海外基金