Analysis of molecular mechanisms of anti-viral response in insects

在缺乏适应性免疫的昆虫中，细胞凋亡和整体蛋白质合成停止(宿主细胞和病毒中的蛋白质合成停止)是主要的抗病毒防御机制。为了阐明病毒感染后导致细胞凋亡和全球蛋白质合成停止的分子机制，我们在培养的昆虫细胞中进行了感染核型多角体病毒(NPV)的实验。我们鉴定并鉴定了几个病毒和细胞基因，它们参与了细胞凋亡和全球蛋白质合成停滞的调控。

Apoptosis and global protein synthesis shutdown (shutdown of protein synthesis in both host cells and viruses) serve as major anti-viral defense mechanisms in the insects, which lack adaptive immunity. To elucidate molecular mechanisms that underlie apoptosis and global protein synthesis shutdown induced upon virus infection, we have conducted experiments in cultured insect cells infected with nucleopolyhedroviruses (NPVs). We identified and characterized several viral and cellular genes that are involved in the regulation of apoptosis and global protein synthesis shutdown.