Efficient Synthesis of Natural Products Having Intriguing Biological Activities Useful for Drug Discovery

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We have studied on the total synthesis of natural products having intriguing biological activities useful for drug discovery. As a result, we have developed efficient methodologies for the synthesis of dyshiherbaine, a glutamate receptor agonist, phoslactomycin B and fostriecin, PP2A inhibitors, and neooxazolomycin, an antitumor antibiotic. In addition, we have developed a new methodology for the construction of heterocycles which relies on an In(III)-catalyzed Conia-ene reaction, and achieved the total synthesis of salinosporamide A, a proteasome inhibitor.