Development of single genome DNA methylation detection device for epigenetics analysis

我们成功开发了一种新的DNA甲基化分析方法。我们的方法在微流控装置中通过流动或纳米空间延长单个DNA，并用甲基化点特异性量子点检测甲基化位点。因此，我们不需要像PCR那样麻烦的程序，可以确定甲基化位点的位置，也可以在单分子水平上检测甲基化，这是目前甲基化分析方法所无法做到的。这些优点将使我们的方法应用于医学诊断。

We successfully developed novel DNA methylation analysis method. Our method elongates single DNA by flow or nanospace in the microfluidic device and detect methylation site with methylation point specific quantum-dots. Therefore, we need no troublesome procedures like PCR and can identify the location of methylation site as well as can detect methylation in single molecule level, which cannot attain by current methylation analysis method. These advantages would permit our method to be applied for medical diagnosis.