The mechanism of neural processing in the pontine nuclei that link the cerebrum to the cerebellum

连接大脑和小脑的脑桥核的神经处理机制

• 批准号: 21800056
• 负责人: ISHIKAWA Taro
• 金额: $ 1.7万
• 依托单位: Jikei University School of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Research Activity Start-up
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-21800056/
• 关键词: 神経科学; 生理学; 薬理学; 脳・神経

The frequency of action potential firing of mossy-fiber projecting neurons in the pontine nuclei and the trigeminal nuclei were investigated. In the slice preparation, neither the pontine cells nor trigeminal cells showed high-frequency firings exceeding 500 Hz. This finding was in striking contrast to the high-frequency firing of mossy fibers that had been observed in anaesthetized animals in vivo. Therefore, it is suggested that, in the in vivo preparation, a mechanism that enhances cellular excitability might have a significant effect.

研究了三叉神经核和脑桥核的苔藓纤维投射神经元动作电位放电频率。在切片制备中，脑桥细胞和三叉神经细胞均未显示超过500 Hz的高频放电。这一发现与在麻醉动物体内观察到的苔藓纤维的高频放电形成鲜明对比。因此，这表明，在体内制备中，增强细胞兴奋性的机制可能具有显着的效果。

项目成果

Multisensory interactions in single cerebellar granule cells in vivo

体内单个小脑颗粒细胞的多感觉相互作用

• 发表时间: 2009
• 作者: Shimuta M;Ishikawa T;Hausser M
• 通讯作者: Hausser M

The origin of high-frequency firing pattern of the cerebellar mossy fibers

小脑苔藓纤维高频放电模式的起源

• 发表时间: 2011
• 作者: Ishikawa T;Shimuta M;Li WB
• 通讯作者: Li WB

Multisensory signals in single cerebellar granule cells in vivo

体内单个小脑颗粒细胞的多感觉信号

• 发表时间: 2009
• 作者: Ishikawa T;Shimuta M;Hausser M
• 通讯作者: Hausser M

Multisensory signals in single cerebellar granule cells in vivo.

体内单个小脑颗粒细胞的多感觉信号。

• 发表时间: 2009
• 作者: Yamauchi J;Ishii N.;宮崎美智子;杉本勝俊;石川太郎
• 通讯作者: 石川太郎