Mechanism of hematopoietic impairment due to abnormal zinc metabolism

锌代谢异常导致造血功能损害的机制

• 批准号: 21800073
• 负责人: KONOMI Aki
• 金额: $ 1.53万
• 依托单位: Aichi Gakusen University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Research Activity Start-up
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-21800073/
• 关键词: 亜鉛; 造血; 栄養; 鉄不応性貧血; エリスロポエチン; 難治性造血障害; 栄養学; 貧血; ゲノミクス

Thirty 3-week-old male SD rats were assigned into 3 groups of 10 for the 4-week study. Difference between groups was statistically analyzed by Fisher's PLSD. P value less than 0.05 was considered significant. Plasma EPO concentration of zinc-deficient group was significantly decreased compared with control group, and pair-fed group was marginally decreased compared with control group (P=0.056). Kidney cortex EPO concentration was decreased in zinc-deficient group compared with pair-fed group. Kidney cortex EPO concentration in pair-fed group was higher than that of control group but the difference was not significant. No significant difference was observed in kidney medulla EPO concentration.

为期4周的研究，将30个3周大的雄性SD大鼠分为3组10。 Fisher的PLSD统计分析了组之间的差异。 P值小于0.05被认为是显着的。与对照组相比，锌缺陷组的血浆EPO浓度显着降低，与对照组相比，配对组略有降低（P = 0.056）。与配对组相比，锌缺陷组的肾脏皮质EPO浓度降低。配对组中的肾脏皮质EPO浓度高于对照组的EPO浓度，但差异并不显着。在肾脏髓质EPO浓度中未观察到显着差异。

项目成果

Changes of erythropoietin concentration in plasma and kidney induced by zinc deficiency

缺锌引起的血浆和肾脏促红细胞生成素浓度的变化

• 发表时间: 2010
• 作者: Aki Konomi;Katsuhiko Yokoi.
• 通讯作者: Katsuhiko Yokoi.

重度鉄欠乏ラットに見られた血液生化学検査値の異常

严重缺铁大鼠血液生化检测值异常

• 发表时间: 2010
• 作者: 横井克彦;許斐亜紀;小田木美喜
• 通讯作者: 小田木美喜

Iron and zinc deficiencies affect zinc kinetic parameters in rats.

铁和锌缺乏会影响大鼠的锌动力学参数。

• 发表时间: 2009
• 作者: Katsuhiko Yokoi;Aki Konomi
• 通讯作者: Aki Konomi

鉄・亜鉛の同時もしくは単独欠乏が血液生化学検査値に及ぼす影響

铁、锌同时或单独缺乏对血液生化检测值的影响

• 发表时间: 2009
• 作者: 許斐亜紀;横井克彦
• 通讯作者: 横井克彦

過剰量のルビジウムがラットの血漿生化学パラメーターに及ぼす影響

过量铷对大鼠血浆生化参数的影响

• 发表时间: 2010
• 作者: 内田由佳;許斐亜紀;横井克彦
• 通讯作者: 横井克彦