Study for the mechanism linking intracellular amyloid precursor protein transport and lipid metabolism

阿尔茨海默病的一个主要病理标志是老年斑中淀粉样蛋白β（Aβ）的积累。Aβ由淀粉样前体蛋白（APP）产生。在这项研究中，我发现用24 S-羟基胆固醇（脑特异性氧化固醇）处理，导致细胞内APP从内质网向高尔基体运输的抑制，导致Aβ产生减少。此外，在24 S-羟基胆固醇的存在下，与APP相关的几个候选蛋白被鉴定。

A major pathological hallmark of Alzheimer's disease is the accumulation of Amyloid β(Aβ) in senile plaques. Aβ is generated from Amyloid precursor protein (APP). In this study, I found that the treatment with 24S-hydroxycholesterol, which is the brain-specific oxysterol, caused the inhibition of intracellular APP trafficking from endoplasmic reticulum to Golgi, resulting the reduction of Aβ production. In addition, several candidate proteins, which were associated with APP in the presence of 24S-hydroxycholesterol, were indentified.