Identification of the molecular mechanisms that contribute to promoting the effect of rehabilitation after spinal cord injury

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To identify the mechanisms that contribute to promoting the effect of rehabilitation after spinal cord injury (SCI), we established two different experimental rat models in order to evaluate the efficacy of rehabilitation. When investigating the rat model without rehabilitation effects, by using Tail-suspention (the absence of load-related afferents from hindlimb in the early stage of SCI), we observed noticeable inhibitory effects on the recovery of locomotor function. Our findings demonstrated that load-related afferents may assume an important role for the promoting the effects of rehabilitation.