Identification of development and regulatory mechanisms of spasticity following spinal cord injury

为了明确脊髓损伤后出现的痉挛如何影响运动功能恢复的机制，我们建立了啮齿类动物后肢出现痉挛行为症状的模型，并建立了评估痉挛和反射亢进的方法。我们的多学科分析结果表明，脊髓损伤后早期失瘫肢体负荷导致与痉挛相关的运动恢复的不可逆抑制，并为痉挛发展的机制提供了见解。

To identify the mechanism how spasticity, appeared after spinal cord injury (SCI), impairs the recovery of locomotor function, we established the rodent model that develops symptoms of spastic behavior in hindlimb, and developed methods to evaluate spasticity and hyperreflexia. Our findings of a multidisciplinary analysis demonstrated that loss of paretic limb loading early after SCI induced irreversible inhibition of locomotor recovery relating to spasticity, and provided insight into mechanisms in the development of spasticity.