Infection risk to wildlife populations and immune suppression induced by environmental chemicals

环境化学物质引起的野生动物感染风险和免疫抑制

• 批准号: 21810001
• 负责人: IKENAKA Yoshinori
• 金额: $ 1.76万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Research Activity Start-up
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-21810001/
• 关键词: 免疫かく乱; 環境汚染バイオマーカー; 重金属; アフリカ; 飼育動物; GIS; 環境化学物質; 感染症; 免疫抑制; サイトカイン; インターロイキン; アフリカ地域; メタロチオネイン; 野生動物

We investigated about "disease for wildlife caused by environmental chemicals", in particular "immunosuppression" focusing on at the field level. We did our investigation in Republic of Zambia the major industry of the country is mining activity. From our results, we found that due to mining activity, the inflammatory cytokines levels and oxidative stress marker levels in domestic cattle and wild rodents were consider affected by heavy metals exposure. Furthermore, we analyze the correlation between GIS heavy metal concentration data and immune disruption. The results indicated that we couldn't found any correlations among immune disruption, heavy metal concentration in soil, and MT expression levels. Our results suggested that other strong factors such as feeding habitat, infection are affected to the correlation.

我们调查了“环境化学品引起的野生动物疾病”，特别是“免疫抑制”，重点是在现场一级。我们在赞比亚共和国进行了调查，该国的主要产业是采矿活动。从我们的研究结果中，我们发现，由于采矿活动，炎症细胞因子水平和氧化应激标记物水平在国内牛和野生啮齿动物被认为是受重金属暴露。此外，我们分析了GIS重金属浓度数据与免疫干扰的相关性。结果表明，免疫抑制与土壤重金属浓度和MT表达水平之间没有相关性。研究结果表明，其他强相关因素如取食生境、感染等也对相关性有影响。

项目成果

Metal and metalloid contamination in roadside soil and wild rats around a Pb-Zn mine in Kabwe, Zambia

• DOI: 10.1016/j.envpol.2010.09.007
• 发表时间: 2011-01-01
• 期刊: ENVIRONMENTAL POLLUTION
• 影响因子: 8.9
• 作者: Nakayama, Shouta M. M.;Ikenaka, Yoshinori;Ishizuka, Mayumi
• 通讯作者: Ishizuka, Mayumi

The Environmental Pollution in Zambia : Effects of heavy metals observed in wild rats inhabit in mining areas in Zambia.

赞比亚的环境污染：在赞比亚矿区栖息的野生老鼠身上观察到重金属的影响。

• 发表时间: 2010
• 作者: Ikenaka Y;Nakayama S;Hamada K;Muzandu K;Choongo K;Teraoka H;Ishizuka M
• 通讯作者: Ishizuka M

Heavy Metal Pollution in Zambia : The Effects of Heavymetal Pollution in Domestic Cattles.

赞比亚的重金属污染：重金属污染对家牛的影响。

• 发表时间: 2010
• 作者: Muroya T.;et al.
• 通讯作者: et al.

Concentration and bioaccumulation of 10 metals in soil, sediment, plant and hippopotamus (Hippopotamus amphibius L) in the South Luangwa National

南卢安瓜国家公园土壤、沉积物、植物和河马 (Hippopotamus amphibius L) 中 10 种金属的浓度和生物富集

• 发表时间: 2010
• 作者: Nakayama SMM.;et al.
• 通讯作者: et al.

Metabolic activation of heterocyclic amines and expression of CYP1A1 in the tongue

舌头中杂环胺的代谢激活和 CYP1A1 的表达

• DOI: 10.1093/toxsci/kfq087
• 发表时间: 2010
• 期刊: Toxicol Sci
• 影响因子: 3.8
• 作者: Takiguchi M;Darwish WS;Ikenaka Y;Ohno M;Ishizuka M.
• 通讯作者: Ishizuka M.