Toxicological Research in Africa; The risk assessment that paid attention to drug metabolism species specificity

非洲毒理学研究；

• 批准号: 23710038
• 负责人: IKENAKA Yoshinori
• 金额: $ 3万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23710038/
• 关键词: 生態系影響評価; 異物代謝系; 環境汚染; 第II相抱合反応; シトクロムP450; 種差; Pyrene; 化学物質感受性; アフリカ諸国

We paid attention to a drug metabolism phase II conjugation reaction and determined species specificity of pro-drug metabolism for the wild animal. Sulfate conjugation of pyrene was detected in the pigs which had been thought to have low sulfate conjugation activity by the screening using 11 kinds of mammalian urine. Also, as a result of kinetics analysis, it was found that the enzyme efficiency of the pig was higher than a rat. Whereas, in the investigation carried out in Africa, we obtained amphibians, mammals, avian urine and an organ. As a result of having performed chemical analysis mainly on heavy metal and pesticides, an extremely highly-concentrated chemical was detected in some areas, and the tendency that accumulated a chemical at the level that was higherthan other organism species in birds particularly was observed.

我们注意到了药物代谢的II相结合反应，并对野生动物进行了前药物代谢的物种特异性测定。通过对11种哺乳动物尿液的筛选，在被认为硫酸盐结合活性较低的猪中检测到了芘的硫酸盐结合。此外，通过动力学分析发现，猪的酶效率高于大鼠。然而，在非洲进行的调查中，我们获得了两栖动物、哺乳动物、鸟类尿液和一个器官。由于主要对重金属和农药进行了化学分析，在一些地区检测到了浓度极高的化学物质，特别是在鸟类中观察到了化学物质积累水平高于其他生物物种的趋势。

项目成果

ワルファリン抵抗性メカニズム

华法林耐药机制

• 发表时间: 2013
• 作者: Yabe J;Nakayama SM;Ikenaka Y;Muzandu K;Ishizuka M;Umemura T.;Yoshinori Ikenaka;池中良徳;池中良徳
• 通讯作者: 池中良徳

魚類における異物代謝機構の特徴と種差：多環芳香族炭化水素（ＰＡＨ）に対する生体防御

鱼类外源代谢机制的特征和物种差异：多环芳烃（PAH）的生物防御

• 发表时间: 2012
• 作者: Kohei Fujii;Hidetoshi Yamashita and Shinichiro Okushima;小栗真美
• 通讯作者: 小栗真美

GIS-based source estimation of Cu pollution in Lake Itezhi-tezhi and metal accumulation profiles in Oreochromis sp. and other fish species from both and laboratory studies

基于GIS的伊特支-特支湖铜污染源估算和Oreochromis sp的金属积累剖面。

• 发表时间: 2011
• 作者: Shouta M.M. Nakayama;Yoshinori Ikenaka;Kaampwe Muzandu;Kennedy Choongo;John Yabe;Taro Muroya;Shigeho Ijiri;Takashi Umemura;Mayumi Ishizuka
• 通讯作者: Mayumi Ishizuka

ガーナの金鉱山周辺（オブアシ自治区）における金属汚染と野生ラットにおける毒性影響評価

加纳（奥布阿西自治区）金矿周围金属污染及对野生大鼠的毒性影响评估

• 发表时间: 2011
• 作者: YARED Beyene;Yoshinori IKENAKA;Kensuke WATANABE;Aksorn SAENGTIENCHAI;Shouta NAKAYAMA;Mayumi ISHIZUKA;大谷豪，池中良徳，中山翔太，Osei Akoto，Joseph APAU，Elvis BAIDOO,石塚真由美
• 通讯作者: 大谷豪，池中良徳，中山翔太，Osei Akoto，Joseph APAU，Elvis BAIDOO,石塚真由美

北海道大学アフリカ研究会

北海道大学非洲研究小组