a novel approach to create and characterize bone and bone marrow by the combination of tissue engineering and hematology

在含有速激肽家族神经肽P物质的明胶水凝胶植入部位周围可诱导血管生成。此外，还观察到植入部位周围有粒细胞聚集，这是一种具有血管生成活性的循环细胞。可以想象，SP的控释有效地诱导了粒细胞从血液循环到植入部位的募集和随后的激活，从而促进了血管生成。

Angiogenesis was induced around the implanted site of gelatin hydrogels incorporating Substance P, a member of tachykinin family neuropeptides. In addition, accumulation of granulocytes, one of the circulating cells with angiogenic activities, around the implanted sites was observed. It is conceivable that the controlled release of SP efficiently induced the recruitment and the subsequent activation of granulocytes from the blood circulation into the site implanted, resulting in enhanced angiogenesis.